Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 165289..165793 Replicon plasmid pCM034-189
Accession NZ_CP086148
Organism Clostridium estertheticum strain CM034

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LL127_RS22190 Protein ID WP_151553814.1
Coordinates 165536..165793 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL127_RS22185 Protein ID WP_151553813.1
Coordinates 165289..165543 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL127_RS22150 (LL127_22095) 160534..161541 + 1008 WP_226130606.1 metallophosphoesterase -
LL127_RS22155 (LL127_22100) 161740..161937 - 198 WP_226130755.1 hypothetical protein -
LL127_RS22160 162245..162367 - 123 WP_264169965.1 hypothetical protein -
LL127_RS22165 (LL127_22105) 162367..162651 - 285 WP_226130607.1 hypothetical protein -
LL127_RS22170 (LL127_22110) 162851..163375 - 525 WP_226130608.1 hypothetical protein -
LL127_RS22175 (LL127_22115) 163864..164442 + 579 WP_151553790.1 tyrosine-type recombinase/integrase -
LL127_RS22180 (LL127_22120) 164552..165127 - 576 WP_226130609.1 hypothetical protein -
LL127_RS22185 (LL127_22125) 165289..165543 + 255 WP_151553813.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL127_RS22190 (LL127_22130) 165536..165793 + 258 WP_151553814.1 Txe/YoeB family addiction module toxin Toxin
LL127_RS22195 (LL127_22135) 166103..167056 - 954 WP_226130610.1 methionyl-tRNA formyltransferase -
LL127_RS22200 (LL127_22140) 167374..168993 - 1620 WP_226130611.1 polysaccharide biosynthesis protein -
LL127_RS22205 (LL127_22145) 169109..170074 - 966 WP_226130612.1 ketopantoate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..189172 189172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.55 Da        Isoelectric Point: 6.9774

>T222624 WP_151553814.1 NZ_CP086148:165536-165793 [Clostridium estertheticum]
MNKIFSEVSWEHYVYWQSEDKKILRKINELIKDIERNGNEGLGKPEALKHELVGYWSRRITDVHRLIYSIDDENIYVASC
KGHYH

Download         Length: 258 bp

>T222624 NZ_CP117974:6819433-6819732 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9805.16 Da        Isoelectric Point: 5.1086

>AT222624 WP_151553813.1 NZ_CP086148:165289-165543 [Clostridium estertheticum]
MIAIGYSNARQNFKNYCDKATKDFETIIITRERGDNVVMLSESAYNNLMENLYVRSDPTYYNELLKSIDQLKMGKGIRKE
LLDE

Download         Length: 255 bp

>AT222624 NZ_CP117974:6819729-6820019 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References