Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 218435..218939 Replicon plasmid pCF016-270
Accession NZ_CP086141
Organism Clostridium estertheticum strain CF016

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LL065_RS24995 Protein ID WP_151553814.1
Coordinates 218682..218939 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL065_RS24990 Protein ID WP_151553813.1
Coordinates 218435..218689 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL065_RS24965 (LL065_24950) 214403..214933 - 531 WP_226139890.1 hypothetical protein -
LL065_RS24970 (LL065_24955) 215010..215534 - 525 WP_226139896.1 hypothetical protein -
LL065_RS24975 (LL065_24960) 215979..216500 - 522 WP_226139899.1 hypothetical protein -
LL065_RS24980 (LL065_24965) 217016..217594 + 579 WP_151553790.1 tyrosine-type recombinase/integrase -
LL065_RS24985 (LL065_24970) 217698..218273 - 576 WP_226139906.1 hypothetical protein -
LL065_RS24990 (LL065_24975) 218435..218689 + 255 WP_151553813.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL065_RS24995 (LL065_24980) 218682..218939 + 258 WP_151553814.1 Txe/YoeB family addiction module toxin Toxin
LL065_RS25000 (LL065_24985) 219032..220441 - 1410 WP_220708120.1 group II intron reverse transcriptase/maturase -
LL065_RS25005 (LL065_24990) 220525..220692 - 168 WP_226141163.1 hypothetical protein -
LL065_RS25010 (LL065_24995) 221319..222062 + 744 WP_226141161.1 tyrosine-type recombinase/integrase -
LL065_RS25015 (LL065_25000) 222206..223171 + 966 WP_226141159.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..269589 269589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.55 Da        Isoelectric Point: 6.9774

>T222623 WP_151553814.1 NZ_CP086141:218682-218939 [Clostridium estertheticum]
MNKIFSEVSWEHYVYWQSEDKKILRKINELIKDIERNGNEGLGKPEALKHELVGYWSRRITDVHRLIYSIDDENIYVASC
KGHYH

Download         Length: 258 bp

>T222623 NZ_CP117974:6576270-6576548 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9805.16 Da        Isoelectric Point: 5.1086

>AT222623 WP_151553813.1 NZ_CP086141:218435-218689 [Clostridium estertheticum]
MIAIGYSNARQNFKNYCDKATKDFETIIITRERGDNVVMLSESAYNNLMENLYVRSDPTYYNELLKSIDQLKMGKGIRKE
LLDE

Download         Length: 255 bp

>AT222623 NZ_CP117974:6576560-6576865 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCTGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References