Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 536983..537893 Replicon plasmid pPA_DBM3797_1
Accession NZ_CP086134
Organism Pantoea agglomerans strain DBM 3797

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LKW31_RS21595 Protein ID WP_228312741.1
Coordinates 537423..537893 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LKW31_RS21590 Protein ID WP_022624589.1
Coordinates 536983..537426 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW31_RS21565 (LKW31_21590) 533097..533996 - 900 WP_228312738.1 alpha/beta hydrolase -
LKW31_RS21570 (LKW31_21595) 534047..534661 - 615 WP_228312739.1 TetR/AcrR family transcriptional regulator -
LKW31_RS21575 (LKW31_21600) 534875..535292 + 418 Protein_512 LysR substrate-binding domain-containing protein -
LKW31_RS21580 (LKW31_21605) 535327..536316 - 990 WP_228312740.1 aldo/keto reductase -
LKW31_RS21585 (LKW31_21610) 536342..536567 - 226 Protein_514 aldo/keto reductase -
LKW31_RS21590 (LKW31_21615) 536983..537426 + 444 WP_022624589.1 DUF2384 domain-containing protein Antitoxin
LKW31_RS21595 (LKW31_21620) 537423..537893 + 471 WP_228312741.1 RES family NAD+ phosphorylase Toxin
LKW31_RS21600 (LKW31_21625) 538065..539096 + 1032 WP_031594315.1 AI-2E family transporter -
LKW31_RS21605 (LKW31_21630) 539085..541814 - 2730 WP_228312742.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..555522 555522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(32-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17528.97 Da        Isoelectric Point: 4.7790

>T222613 WP_228312741.1 NZ_CP086134:537423-537893 [Pantoea agglomerans]
MIFYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDALIQTADIT
ELPANWADEDAPAELADYGDAWCSACDAVALRVPSALSPVEYNYLLNPEHPEFFRIIQQAEAIPFRFDRRLKPDRK

Download         Length: 471 bp

>T222613 NZ_CP117971:4123206-4123484 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16474.91 Da        Isoelectric Point: 9.9250

>AT222613 WP_022624589.1 NZ_CP086134:536983-537426 [Pantoea agglomerans]
MKTFSFSANKTRPPRLWQAAGLNNADGVALLGQINEGLDGNVAHLIVNWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEALKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Download         Length: 444 bp

>AT222613 NZ_CP117971:4122943-4123203 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References