Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2228692..2229322 Replicon chromosome
Accession NZ_CP086133
Organism Pantoea agglomerans strain DBM 3797

Toxin (Protein)


Gene name hicA Uniprot ID A0A379AGD8
Locus tag LKW31_RS10340 Protein ID WP_010245321.1
Coordinates 2229140..2229322 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A349IF99
Locus tag LKW31_RS10335 Protein ID WP_010245317.1
Coordinates 2228692..2229117 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW31_RS10320 (2223895) 2223895..2225049 + 1155 WP_228312151.1 efflux RND transporter periplasmic adaptor subunit -
LKW31_RS10325 (2225062) 2225062..2228214 + 3153 WP_228312152.1 multidrug efflux RND transporter permease subunit OqxB -
LKW31_RS10330 (2228303) 2228303..2228656 - 354 WP_228312153.1 type II toxin-antitoxin system HicB family antitoxin -
LKW31_RS10335 (2228692) 2228692..2229117 - 426 WP_010245317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LKW31_RS10340 (2229140) 2229140..2229322 - 183 WP_010245321.1 type II toxin-antitoxin system HicA family toxin Toxin
LKW31_RS10345 (2229595) 2229595..2230811 + 1217 WP_172608054.1 IS3 family transposase -
LKW31_RS10350 (2230841) 2230841..2231323 - 483 WP_228312154.1 Rrf2 family transcriptional regulator -
LKW31_RS10355 (2231531) 2231531..2232715 - 1185 WP_228312155.1 MFS transporter -
LKW31_RS10360 (2232918) 2232918..2233847 + 930 WP_033771708.1 DNA replication terminus site-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IS/Tn oqxB - 2225062..2230811 5749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7000.12 Da        Isoelectric Point: 11.0643

>T222604 WP_010245321.1 NZ_CP086133:c2229322-2229140 [Pantoea agglomerans]
MKYSEFRRWLIQQGAILTKHRSGSSHFKVFLGDRQSIFPDHGAKEMPEGTRRKILKDLGL

Download         Length: 183 bp

>T222604 NZ_CP117971:2317846-2317949 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15499.78 Da        Isoelectric Point: 4.8263

>AT222604 WP_010245317.1 NZ_CP086133:c2229117-2228692 [Pantoea agglomerans]
MFNYAVRLTHDAKTDTYEVSCRDLPLLHSVGDTVEEALAEAEDGLVTAISLEMDTRRPIPVASKPLEGEYIVSVPVLVAM
KAALYNAMIETGTRKVDLARQLGVNGPQVDRLLDVEHSSKVENVELALAQLGRKARIEIRT

Download         Length: 426 bp

>AT222604 NZ_CP117971:c2317987-2317716 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379AGD8

Antitoxin

Source ID Structure
AlphaFold DB A0A349IF99

References