Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2131490..2133051 Replicon chromosome
Accession NZ_CP086133
Organism Pantoea agglomerans strain DBM 3797

Toxin (Protein)


Gene name hipA Uniprot ID A0A8X8J3D8
Locus tag LKW31_RS09875 Protein ID WP_022625645.1
Coordinates 2131738..2133051 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LKW31_RS09870 Protein ID WP_010670157.1
Coordinates 2131490..2131738 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW31_RS09850 (2126737) 2126737..2128962 + 2226 WP_158131692.1 iron ABC transporter permease -
LKW31_RS09855 (2128959) 2128959..2130020 + 1062 WP_033757668.1 ABC transporter ATP-binding protein -
LKW31_RS09860 (2130044) 2130044..2130838 + 795 WP_158131693.1 inositol monophosphatase family protein -
LKW31_RS09865 (2130872) 2130872..2131309 - 438 Protein_1920 GNAT family N-acetyltransferase -
LKW31_RS09870 (2131490) 2131490..2131738 + 249 WP_010670157.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LKW31_RS09875 (2131738) 2131738..2133051 + 1314 WP_022625645.1 type II toxin-antitoxin system HipA family toxin Toxin
LKW31_RS09880 (2133156) 2133156..2133362 + 207 WP_010244885.1 type II toxin-antitoxin system MqsA family antitoxin -
LKW31_RS09885 (2133534) 2133534..2134955 + 1422 WP_158131694.1 M24 family metallopeptidase -
LKW31_RS09890 (2135031) 2135031..2137076 + 2046 WP_157352163.1 FUSC family protein -
LKW31_RS09895 (2137307) 2137307..2137642 - 336 WP_022625647.1 gamma-glutamylcyclotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49147.73 Da        Isoelectric Point: 8.4280

>T222603 WP_022625645.1 NZ_CP086133:2131738-2133051 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKALTSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

>T222603 NZ_CP117971:2128041-2128295 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9319.56 Da        Isoelectric Point: 5.0775

>AT222603 WP_010670157.1 NZ_CP086133:2131490-2131738 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQVHDED
EW

Download         Length: 249 bp

>AT222603 NZ_CP117971:2127793-2128044 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References