Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
| Location | 248955..249567 | Replicon | chromosome |
| Accession | NZ_CP086129 | ||
| Organism | Streptococcus agalactiae strain MIN-181 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A8G2N8L3 |
| Locus tag | LLZ90_RS01440 | Protein ID | WP_000384860.1 |
| Coordinates | 248955..249290 (-) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q8E7D2 |
| Locus tag | LLZ90_RS01445 | Protein ID | WP_000259017.1 |
| Coordinates | 249280..249567 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LLZ90_RS01415 (LLZ90_01415) | 244153..244794 | + | 642 | WP_000591144.1 | hypothetical protein | - |
| LLZ90_RS01420 (LLZ90_01420) | 245094..245969 | + | 876 | WP_000421240.1 | hypothetical protein | - |
| LLZ90_RS01425 (LLZ90_01425) | 246005..246439 | + | 435 | WP_001220479.1 | hypothetical protein | - |
| LLZ90_RS01430 (LLZ90_01430) | 246756..248012 | + | 1257 | WP_000122836.1 | MobV family relaxase | - |
| LLZ90_RS01435 (LLZ90_01435) | 248180..248650 | + | 471 | WP_000130119.1 | hypothetical protein | - |
| LLZ90_RS01440 (LLZ90_01440) | 248955..249290 | - | 336 | WP_000384860.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LLZ90_RS01445 (LLZ90_01445) | 249280..249567 | - | 288 | WP_000259017.1 | hypothetical protein | Antitoxin |
| LLZ90_RS01450 (LLZ90_01450) | 250074..250364 | + | 291 | WP_000078283.1 | WXG100 family type VII secretion target | - |
| LLZ90_RS01455 (LLZ90_01455) | 250466..250873 | + | 408 | WP_000749954.1 | hypothetical protein | - |
| LLZ90_RS01460 (LLZ90_01460) | 250873..251433 | + | 561 | WP_001865562.1 | hypothetical protein | - |
| LLZ90_RS01465 (LLZ90_01465) | 251406..252086 | + | 681 | WP_001865565.1 | hypothetical protein | - |
| LLZ90_RS01470 (LLZ90_01470) | 252071..252457 | + | 387 | WP_000259069.1 | hypothetical protein | - |
| LLZ90_RS01475 (LLZ90_01475) | 252491..252772 | + | 282 | WP_000052406.1 | hypothetical protein | - |
| LLZ90_RS01480 (LLZ90_01480) | 253615..254475 | + | 861 | WP_000477654.1 | Rgg/GadR/MutR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 240986..249841 | 8855 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 13227.87 Da Isoelectric Point: 4.5348
>T222597 WP_000384860.1 NZ_CP086129:c249290-248955 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK
Download Length: 336 bp
>T222597 NZ_CP117971:c954246-953782 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10906.50 Da Isoelectric Point: 4.7271
>AT222597 WP_000259017.1 NZ_CP086129:c249567-249280 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL
Download Length: 288 bp
>AT222597 NZ_CP117971:c954581-954246 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|