Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5041262..5041887 Replicon chromosome
Accession NZ_CP086128
Organism Klebsiella pneumoniae strain MIN-109

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLZ91_RS24390 Protein ID WP_234573885.1
Coordinates 5041262..5041645 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LLZ91_RS24395 Protein ID WP_004150355.1
Coordinates 5041645..5041887 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ91_RS24375 (LLZ91_24415) 5038628..5039530 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LLZ91_RS24380 (LLZ91_24420) 5039527..5040162 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LLZ91_RS24385 (LLZ91_24425) 5040159..5041088 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LLZ91_RS24390 (LLZ91_24430) 5041262..5041645 - 384 WP_234573885.1 type II toxin-antitoxin system VapC family toxin Toxin
LLZ91_RS24395 (LLZ91_24435) 5041645..5041887 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LLZ91_RS24400 (LLZ91_24440) 5042092..5043009 + 918 WP_004895173.1 alpha/beta hydrolase -
LLZ91_RS24405 (LLZ91_24445) 5043023..5043964 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
LLZ91_RS24410 (LLZ91_24450) 5044009..5044446 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LLZ91_RS24415 (LLZ91_24455) 5044443..5045303 - 861 WP_234246549.1 virulence factor BrkB family protein -
LLZ91_RS24420 (LLZ91_24460) 5045297..5045896 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14340.54 Da        Isoelectric Point: 6.8806

>T222596 WP_234573885.1 NZ_CP086128:c5041645-5041262 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWLEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T222596 NZ_CP117971:563985-564092 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT222596 WP_004150355.1 NZ_CP086128:c5041887-5041645 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT222596 NZ_CP117971:c563937-563871 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References