Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3834138..3834757 Replicon chromosome
Accession NZ_CP086128
Organism Klebsiella pneumoniae strain MIN-109

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LLZ91_RS18630 Protein ID WP_002892050.1
Coordinates 3834539..3834757 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LLZ91_RS18625 Protein ID WP_002892066.1
Coordinates 3834138..3834512 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ91_RS18615 (LLZ91_18640) 3829290..3830483 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LLZ91_RS18620 (LLZ91_18645) 3830506..3833652 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LLZ91_RS18625 (LLZ91_18650) 3834138..3834512 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LLZ91_RS18630 (LLZ91_18655) 3834539..3834757 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LLZ91_RS18635 (LLZ91_18660) 3834920..3835486 + 567 WP_002892030.1 maltose O-acetyltransferase -
LLZ91_RS18640 (LLZ91_18665) 3835458..3835598 - 141 WP_032410934.1 hypothetical protein -
LLZ91_RS18645 (LLZ91_18670) 3835619..3836089 + 471 WP_002892026.1 YlaC family protein -
LLZ91_RS18650 (LLZ91_18675) 3836064..3837515 - 1452 WP_234573800.1 PLP-dependent aminotransferase family protein -
LLZ91_RS18655 (LLZ91_18680) 3837616..3838314 + 699 WP_117260135.1 GNAT family protein -
LLZ91_RS18660 (LLZ91_18685) 3838311..3838451 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LLZ91_RS18665 (LLZ91_18690) 3838451..3838714 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T222593 WP_002892050.1 NZ_CP086128:3834539-3834757 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T222593 NZ_CP117970:2644170-2644265 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT222593 WP_002892066.1 NZ_CP086128:3834138-3834512 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT222593 NZ_CP117970:c2644364-2644300 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References