22259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4245904..4246531 Replicon chromosome
Accession NC_009633
Organism Alkaliphilus metalliredigens QYMF

Toxin (Protein)


Gene name pemK Uniprot ID A6TVK6
Locus tag AMET_RS20335 Protein ID WP_012065172.1
Coordinates 4245904..4246254 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A6TVK7
Locus tag AMET_RS20340 Protein ID WP_012065173.1
Coordinates 4246256..4246531 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMET_RS20320 4241574..4242680 - 1107 WP_012065169.1 polysaccharide pyruvyl transferase CsaB -
AMET_RS20325 4242673..4244844 - 2172 WP_012065170.1 hypothetical protein -
AMET_RS24585 4245167..4245700 - 534 WP_012065171.1 hypothetical protein -
AMET_RS20335 4245904..4246254 - 351 WP_012065172.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AMET_RS20340 4246256..4246531 - 276 WP_012065173.1 ribbon-helix-helix protein, CopG family Antitoxin
AMET_RS20345 4246716..4247891 - 1176 WP_012065174.1 alanine racemase -
AMET_RS20350 4247904..4248563 - 660 WP_012065175.1 outer membrane lipoprotein-sorting protein -
AMET_RS20355 4248663..4249031 - 369 WP_012065176.1 holo-ACP synthase -
AMET_RS20360 4249203..4249823 - 621 WP_012065177.1 hypothetical protein -
AMET_RS20365 4250079..4251041 + 963 WP_157047320.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12863.91 Da        Isoelectric Point: 5.1568

>T22259 WP_012065172.1 NC_009633:c4246254-4245904 [Alkaliphilus metalliredigens QYMF]
VVVKRGDIYYADLSPVIGSEQGGVRPVLIIQNDIGNRYSPTVIVAAITSQINKAKLPTHIEITASDYGLPKDSVVLLEQI
RTIDKRRLEEKVGHFDEEMMIKVNEALLISCGLIDF

Download         Length: 351 bp

>T22259 NC_009633:c4246254-4245904 [Alkaliphilus metalliredigens QYMF]
GTGGTTGTCAAAAGAGGAGACATCTATTATGCAGATCTAAGTCCTGTCATTGGATCGGAGCAAGGGGGCGTTAGGCCGGT
TTTAATCATTCAAAATGATATCGGAAACCGGTACAGTCCAACGGTGATTGTTGCAGCAATTACGTCTCAAATTAACAAGG
CAAAGTTACCAACTCATATTGAAATCACTGCCTCTGACTATGGTTTGCCTAAAGACTCTGTTGTTTTACTAGAACAAATC
AGGACGATTGATAAAAGACGATTAGAAGAAAAAGTCGGACACTTTGATGAGGAAATGATGATTAAAGTAAATGAAGCGTT
ATTAATTAGCTGTGGATTGATAGATTTTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10548.12 Da        Isoelectric Point: 4.3356

>AT22259 WP_012065173.1 NC_009633:c4246531-4246256 [Alkaliphilus metalliredigens QYMF]
VADSKRIMISLPDSLLQEVDGIVSMEQTNRSEFIREAMKLYIRERNKMELREKMITGYQEMGYINLAIAELGLSLDISSL
EHYETQMAECE

Download         Length: 276 bp

>AT22259 NC_009633:c4246531-4246256 [Alkaliphilus metalliredigens QYMF]
GTGGCCGACTCTAAACGAATTATGATTAGTCTTCCGGACAGTCTTTTACAAGAGGTAGATGGGATTGTTTCTATGGAACA
AACAAACCGAAGTGAATTTATTCGTGAAGCAATGAAACTCTACATTAGGGAGAGAAATAAAATGGAGTTAAGAGAGAAGA
TGATCACTGGGTATCAAGAAATGGGATATATTAACTTAGCCATTGCAGAACTTGGATTGAGTTTAGATATTTCTTCATTA
GAGCACTATGAGACTCAAATGGCGGAGTGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TVK6

Antitoxin

Source ID Structure
AlphaFold DB A6TVK7

References