Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 98378..98895 Replicon plasmid pSMED03
Accession NC_009622
Organism Sinorhizobium medicae WSM419

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag SMED_RS31590 Protein ID WP_086017937.1
Coordinates 98378..98635 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SMED_RS31595 Protein ID WP_017266772.1
Coordinates 98635..98895 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMED_RS31560 93806..94582 + 777 WP_011971063.1 amino acid ABC transporter ATP-binding protein -
SMED_RS31565 94701..94916 + 216 Protein_100 phage integrase N-terminal SAM-like domain-containing protein -
SMED_RS31570 95960..96244 + 285 WP_011971061.1 hypothetical protein -
SMED_RS31575 96364..96504 + 141 WP_011971060.1 hypothetical protein -
SMED_RS31580 96912..98021 + 1110 WP_011971059.1 ionic transporter y4hA -
SMED_RS31585 98085..98309 - 225 WP_011971058.1 hypothetical protein -
SMED_RS31590 98378..98635 - 258 WP_086017937.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMED_RS31595 98635..98895 - 261 WP_017266772.1 ribbon-helix-helix domain-containing protein Antitoxin
SMED_RS31600 99270..100026 - 757 Protein_107 IS5 family transposase -
SMED_RS31605 100152..101174 + 1023 WP_011971054.1 IS110 family transposase -
SMED_RS31610 101590..102603 + 1014 Protein_109 IS630 family transposase -
SMED_RS31615 102612..102989 - 378 Protein_110 transposase -
SMED_RS31620 103050..103734 - 685 Protein_111 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..219313 219313


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-68)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9999.46 Da        Isoelectric Point: 10.8333

>T22258 WP_086017937.1 NC_009622:c98635-98378 [Sinorhizobium medicae WSM419]
MKLEWTRKAVSDLGRLHDFLASVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEMSTIYVLRPWH
TRESR

Download         Length: 258 bp

>T22258 NC_009622:c98635-98378 [Sinorhizobium medicae WSM419]
ATGAAGCTCGAGTGGACGCGTAAGGCAGTCTCCGATCTAGGGCGCCTGCATGATTTCCTGGCATCGGTAAATCGGCAAGC
TGCTGCTCGCACTGTGCAATCGTTGACAAGCGCTCCTGCGCGCCTGCTCGAACAACCGCGCATCGGCGAACGGCTGGAGG
AATTCGACCCACGAGAGGTTCGGCGAATTCTCGTTGGCCATTACGAAATGTCGACGATCTACGTGCTGCGGCCTTGGCAT
ACGCGTGAATCACGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9699.11 Da        Isoelectric Point: 5.1200

>AT22258 WP_017266772.1 NC_009622:c98895-98635 [Sinorhizobium medicae WSM419]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWIDQEEERRRLTLEALADVDAGRVIEHHAVQAWADSLDSDK
PLPLPL

Download         Length: 261 bp

>AT22258 NC_009622:c98895-98635 [Sinorhizobium medicae WSM419]
ATGGAAACCAAGGTGCTGACCGCGCACGTGCCACTGCCTCTCGCCGAGAAAGTCGATCAGATCGCCGCCCGCCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGATCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGGGTGATCGAGCACCATGCCGTTCAGGCCTGGGCCGACAGTCTTGACAGCGACAAG
CCGCTACCCTTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References