Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 855136..855675 Replicon chromosome
Accession NZ_CP086125
Organism Mammaliicoccus sciuri strain MIN-177

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag LLZ87_RS04150 Protein ID WP_048540867.1
Coordinates 855304..855675 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag LLZ87_RS04145 Protein ID WP_025904510.1
Coordinates 855136..855303 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ87_RS04120 (LLZ87_04125) 851018..851497 + 480 WP_058612364.1 PH domain-containing protein -
LLZ87_RS04125 (LLZ87_04130) 851487..853007 + 1521 WP_058612363.1 PH domain-containing protein -
LLZ87_RS04130 (LLZ87_04135) 852997..853461 + 465 WP_058612362.1 PH domain-containing protein -
LLZ87_RS04135 (LLZ87_04140) 853493..853855 + 363 WP_058591084.1 holo-ACP synthase -
LLZ87_RS04140 (LLZ87_04145) 853903..855051 + 1149 WP_070369140.1 alanine racemase -
LLZ87_RS04145 (LLZ87_04150) 855136..855303 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LLZ87_RS04150 (LLZ87_04155) 855304..855675 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LLZ87_RS04155 (LLZ87_04160) 855772..856776 + 1005 WP_070373314.1 PP2C family protein-serine/threonine phosphatase -
LLZ87_RS04160 (LLZ87_04165) 856881..857204 + 324 WP_206543273.1 anti-sigma factor antagonist -
LLZ87_RS04165 (LLZ87_04170) 857209..857685 + 477 WP_025904514.1 anti-sigma B factor RsbW -
LLZ87_RS04170 (LLZ87_04175) 857660..858430 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T222579 WP_048540867.1 NZ_CP086125:855304-855675 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T222579 NZ_CP117963:2274162-2274437 [Faecalibacterium prausnitzii]
ATGAAATACGAGATCAAGCCTTCTTCACGATTCAAAAAGGATATGAAGCTGGTCAAAAAGCGTGGTTATGACCCCCGACT
GATTGAAACTGTCATCAAAACACTTGCCAATGGGGAGCCGCTGGACAAAAAGTACAGAGACCATATCCTCGTCGGTGATT
ATTCCGGCTTTCATGAATGTCACATTACACCGGACTGGCTGCTCATCTACCAGATCTATGATGAGGAGCTCTATTTGCTT
TTGTCCCGAACCGGAACACACAGCGATCTCTTTTAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT222579 WP_025904510.1 NZ_CP086125:855136-855303 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT222579 NZ_CP117963:2273896-2274165 [Faecalibacterium prausnitzii]
ATGACAACTTTGAATATTCCGATTGATGAAAAAGTCGAAAAAGAAGCGGAAGAGCTGTTCTCTGATTTTGGTCTTGATAT
TCCTACGGCTGTCAACATCTTTCTGCGGCAGTCCATTCGTGAAAACTGTATTCCCTTCAACATTGAGCGGGAAGTTCCAA
ATGCCGACACGATCGCTGCCATGCGAGAAGCAGAAGAGATGAAAAAACATCCTGAAAAGTATAAAGGCTATCACGATGTG
GATGAAATGATGAAGGATCTGTTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References