222575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465266..3466487 Replicon chromosome
Accession NZ_CP086122
Organism Pseudomonas aeruginosa strain MIN-155

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLZ84_RS15870 Protein ID WP_003114949.1
Coordinates 3465909..3466487 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LLZ84_RS15865 Protein ID WP_003088112.1
Coordinates 3465266..3465820 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ84_RS15840 (LLZ84_15840) 3460834..3461385 + 552 WP_003102727.1 XRE family transcriptional regulator -
LLZ84_RS15845 (LLZ84_15845) 3461382..3461780 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LLZ84_RS15850 (LLZ84_15850) 3461793..3462116 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LLZ84_RS15855 (LLZ84_15855) 3462447..3462908 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LLZ84_RS15860 (LLZ84_15860) 3462913..3465108 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LLZ84_RS15865 (LLZ84_15865) 3465266..3465820 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LLZ84_RS15870 (LLZ84_15870) 3465909..3466487 + 579 WP_003114949.1 HD domain-containing protein Toxin
LLZ84_RS15875 (LLZ84_15875) 3466595..3467782 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LLZ84_RS15880 (LLZ84_15880) 3467772..3469943 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
LLZ84_RS15885 (LLZ84_15885) 3469933..3471210 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T222575 WP_003114949.1 NZ_CP086122:3465909-3466487 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T222575 NZ_CP117962:4068105-4068359 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT222575 WP_003088112.1 NZ_CP086122:3465266-3465820 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT222575 NZ_CP117962:4067857-4068108 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References