222573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1589030..1590725 Replicon chromosome
Accession NZ_CP086122
Organism Pseudomonas aeruginosa strain MIN-155

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag LLZ84_RS07405 Protein ID WP_003112901.1
Coordinates 1589030..1589899 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag LLZ84_RS07410 Protein ID WP_003112902.1
Coordinates 1589892..1590725 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ84_RS07380 (LLZ84_07380) 1585038..1585889 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
LLZ84_RS07385 (LLZ84_07385) 1585930..1586937 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
LLZ84_RS07390 (LLZ84_07390) 1586934..1587710 + 777 WP_003112898.1 ABC transporter permease -
LLZ84_RS07395 (LLZ84_07395) 1587716..1588477 + 762 WP_003112899.1 SDR family oxidoreductase -
LLZ84_RS07400 (LLZ84_07400) 1588491..1589021 + 531 WP_003112900.1 cupin domain-containing protein -
LLZ84_RS07405 (LLZ84_07405) 1589030..1589899 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
LLZ84_RS07410 (LLZ84_07410) 1589892..1590725 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
LLZ84_RS07415 (LLZ84_07415) 1590712..1591509 + 798 WP_003112903.1 SDR family oxidoreductase -
LLZ84_RS07420 (LLZ84_07420) 1591502..1593184 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
LLZ84_RS07425 (LLZ84_07425) 1593195..1593998 + 804 WP_003112905.1 aspartate dehydrogenase -
LLZ84_RS07430 (LLZ84_07430) 1594010..1595494 + 1485 WP_003112906.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T222573 WP_003112901.1 NZ_CP086122:1589030-1589899 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T222573 NZ_CP117962:c3396171-3395098 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT222573 WP_003112902.1 NZ_CP086122:1589892-1590725 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp

>AT222573 NZ_CP117962:c3395105-3394734 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References