Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143084..143589 Replicon chromosome
Accession NZ_CP086122
Organism Pseudomonas aeruginosa strain MIN-155

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LLZ84_RS00660 Protein ID WP_003083773.1
Coordinates 143084..143365 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag LLZ84_RS00665 Protein ID WP_003112628.1
Coordinates 143362..143589 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ84_RS00635 (LLZ84_00635) 138335..139684 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
LLZ84_RS00640 (LLZ84_00640) 139733..140419 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
LLZ84_RS00645 (LLZ84_00645) 140520..141254 + 735 WP_003115036.1 GntR family transcriptional regulator -
LLZ84_RS00650 (LLZ84_00650) 141434..141844 + 411 WP_003101225.1 aegerolysin family protein -
LLZ84_RS00655 (LLZ84_00655) 141876..142784 - 909 WP_003083769.1 LysR family transcriptional regulator -
LLZ84_RS00660 (LLZ84_00660) 143084..143365 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LLZ84_RS00665 (LLZ84_00665) 143362..143589 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
LLZ84_RS00670 (LLZ84_00670) 143765..144385 - 621 WP_003101226.1 hypothetical protein -
LLZ84_RS00675 (LLZ84_00675) 144486..144986 + 501 WP_003112629.1 LEA type 2 family protein -
LLZ84_RS00680 (LLZ84_00680) 145059..145400 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LLZ84_RS00685 (LLZ84_00685) 145482..146909 - 1428 WP_003083784.1 GABA permease -
LLZ84_RS00690 (LLZ84_00690) 147078..148571 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T222572 WP_003083773.1 NZ_CP086122:c143365-143084 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T222572 NZ_CP117962:c3384636-3384307 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT222572 WP_003112628.1 NZ_CP086122:c143589-143362 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT222572 NZ_CP117962:c3384974-3384657 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References