Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 1045725..1046245 Replicon chromosome
Accession NZ_CP086120
Organism Streptomyces gobiensis strain 1_25

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag test1122_RS04855 Protein ID WP_232267915.1
Coordinates 1045991..1046245 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag test1122_RS04850 Protein ID WP_232267914.1
Coordinates 1045725..1045994 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
test1122_RS04830 (test1122_04835) 1040924..1041694 - 771 WP_232267910.1 SDR family oxidoreductase -
test1122_RS04835 (test1122_04840) 1041687..1043123 - 1437 WP_232267911.1 MFS transporter -
test1122_RS04840 (test1122_04845) 1043247..1044269 - 1023 WP_232267912.1 M23 family metallopeptidase -
test1122_RS04845 (test1122_04850) 1044275..1045417 - 1143 WP_232267913.1 SPFH domain-containing protein -
test1122_RS04850 (test1122_04855) 1045725..1045994 + 270 WP_232267914.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
test1122_RS04855 (test1122_04860) 1045991..1046245 + 255 WP_232267915.1 Txe/YoeB family addiction module toxin Toxin
test1122_RS04860 (test1122_04865) 1046373..1047836 + 1464 WP_232267916.1 FAD-dependent oxidoreductase -
test1122_RS04865 (test1122_04870) 1047825..1049147 - 1323 WP_277879794.1 cytochrome P450 -
test1122_RS04870 (test1122_04875) 1049182..1049970 - 789 WP_232267918.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9984.43 Da        Isoelectric Point: 10.0190

>T222571 WP_232267915.1 NZ_CP086120:1045991-1046245 [Streptomyces gobiensis]
VKLAFHPAGWADYLYWQNTDRQVAKRINRLINDVLRDPFTGIGKPEHLKHMAPGAWSRRITDEHRLVYQVKDSEVIILQA
RYHY

Download         Length: 255 bp

>T222571 NZ_CP117962:3248323-3248658 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9891.01 Da        Isoelectric Point: 4.1743

>AT222571 WP_232267914.1 NZ_CP086120:1045725-1045994 [Streptomyces gobiensis]
MSITASEARKRLFPLIEEVNDDATAVEIVSRAGTAYLVPAEEYESLKETAYLLRSPANAERLLRAVRDVATGNYEYRDLI
PVEGEESGE

Download         Length: 270 bp

>AT222571 NZ_CP117962:3248075-3248323 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References