Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 923927..924462 Replicon plasmid pSMED02
Accession NC_009621
Organism Sinorhizobium medicae WSM419

Toxin (Protein)


Gene name relE Uniprot ID A0A6G1WU13
Locus tag SMED_RS29460 Protein ID WP_024325581.1
Coordinates 924187..924462 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A508WV74
Locus tag SMED_RS29455 Protein ID WP_011970754.1
Coordinates 923927..924187 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMED_RS29430 919639..921036 + 1398 WP_011970749.1 sigma-54 dependent transcriptional regulator -
SMED_RS29435 921261..922094 + 834 WP_011970750.1 DUF1614 domain-containing protein -
SMED_RS29440 922185..922793 + 609 WP_011970751.1 DUF1003 domain-containing protein -
SMED_RS29445 923084..923464 + 381 WP_011970752.1 hypothetical protein -
SMED_RS29450 923465..923794 + 330 WP_011970753.1 hypothetical protein -
SMED_RS29455 923927..924187 + 261 WP_011970754.1 ribbon-helix-helix domain-containing protein Antitoxin
SMED_RS29460 924187..924462 + 276 WP_024325581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMED_RS29465 924511..925660 + 1150 Protein_860 site-specific integrase -
SMED_RS29470 925708..925966 - 259 Protein_861 hypothetical protein -
SMED_RS29475 926605..926895 + 291 WP_024325582.1 hypothetical protein -
SMED_RS29480 927738..927989 + 252 WP_011970757.1 WGR domain-containing protein -
SMED_RS29485 928471..928644 + 174 WP_018009181.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1245408 1245408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10822.40 Da        Isoelectric Point: 9.9707

>T22257 WP_024325581.1 NC_009621:924187-924462 [Sinorhizobium medicae WSM419]
MKLEWTSKAVADLGRLYDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTREDR

Download         Length: 276 bp

>T22257 NC_009621:924187-924462 [Sinorhizobium medicae WSM419]
ATGAAGCTTGAGTGGACGAGTAAGGCAGTCGCCGATCTTGGGCGCCTCTATGATTTCCTGGCACCGGTAAATCGGCAAGC
TGCGGCTCGTACTGTGCAATCGTTGACGAGCGCTCCAGCACGCCTGCTCGAACAACCGCGTATCGGCGAACGGCTGGAGG
AATTCGACCCTCGAGAGGTTCGGCGAATTCTCGTTGGCCATTACGAAATACGGTATGAGATCCGGCAGTCGACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAAGACCGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9710.05 Da        Isoelectric Point: 4.6413

>AT22257 WP_011970754.1 NC_009621:923927-924187 [Sinorhizobium medicae WSM419]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDADRVIDHQAVQAWADSLDSDK
PLSLPL

Download         Length: 261 bp

>AT22257 NC_009621:923927-924187 [Sinorhizobium medicae WSM419]
ATGGAAACGAAGGTGCTGACGGCGCACGTACCTCTGCCGCTCGCCGAGAAAGTCGATCAGATCGCGGCCCGGCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCTTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGACCGCGTTATCGATCACCAGGCCGTCCAGGCCTGGGCCGACAGTCTTGATAGTGACAAG
CCGCTATCTTTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G1WU13

Antitoxin

Source ID Structure
AlphaFold DB A0A508WV74

References