Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4425046..4425827 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LLY43_RS21625 Protein ID WP_000626099.1
Coordinates 4425046..4425537 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LLY43_RS21630 Protein ID WP_001110452.1
Coordinates 4425534..4425827 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS21585 (4420232) 4420232..4420474 - 243 WP_197603740.1 hypothetical protein -
LLY43_RS21590 (4420471) 4420471..4420827 - 357 WP_033567083.1 hypothetical protein -
LLY43_RS21595 (4420824) 4420824..4421696 - 873 WP_033567082.1 ParA family protein -
LLY43_RS21600 (4421887) 4421887..4421964 - 78 Protein_4228 helix-turn-helix domain-containing protein -
LLY43_RS21605 (4422055) 4422055..4422387 - 333 WP_001165471.1 MerR family transcriptional regulator -
LLY43_RS21610 (4422459) 4422459..4422836 + 378 WP_000916345.1 EthD family reductase -
LLY43_RS21615 (4423869) 4423869..4423943 + 75 Protein_4231 porin family protein -
LLY43_RS21620 (4424046) 4424046..4424798 + 753 WP_000842434.1 non-specific acid phosphatase -
LLY43_RS21625 (4425046) 4425046..4425537 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LLY43_RS21630 (4425534) 4425534..4425827 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LLY43_RS21635 (4426144) 4426144..4426365 + 222 WP_001576552.1 hypothetical protein -
LLY43_RS21640 (4426630) 4426630..4427505 + 876 WP_000921674.1 AraC family transcriptional regulator -
LLY43_RS21645 (4427502) 4427502..4427789 + 288 WP_001269916.1 transcriptional regulator RtsB -
LLY43_RS21650 (4427812) 4427812..4428027 + 216 WP_001595136.1 hypothetical protein -
LLY43_RS21655 (4428035) 4428035..4428304 + 270 WP_010989096.1 hypothetical protein -
LLY43_RS21660 (4428598) 4428598..4429503 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T222567 WP_000626099.1 NZ_CP086118:c4425537-4425046 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T222567 NZ_CP117962:c2880880-2880416 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT222567 WP_001110452.1 NZ_CP086118:c4425827-4425534 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT222567 NZ_CP117962:c2881215-2880880 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References