Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4214968..4215484 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LLY43_RS20520 Protein ID WP_000220578.1
Coordinates 4214968..4215252 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LLY43_RS20525 Protein ID WP_000212724.1
Coordinates 4215242..4215484 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS20505 (4210180) 4210180..4211832 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
LLY43_RS20510 (4212241) 4212241..4214379 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LLY43_RS20515 (4214500) 4214500..4214964 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LLY43_RS20520 (4214968) 4214968..4215252 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLY43_RS20525 (4215242) 4215242..4215484 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LLY43_RS20530 (4215562) 4215562..4217475 - 1914 WP_001212137.1 BglG family transcription antiterminator -
LLY43_RS20535 (4217492) 4217492..4218232 - 741 WP_000779263.1 KDGP aldolase family protein -
LLY43_RS20540 (4218229) 4218229..4219347 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LLY43_RS20545 (4219331) 4219331..4220464 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T222566 WP_000220578.1 NZ_CP086118:c4215252-4214968 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T222566 NZ_CP117962:c1802777-1802604 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT222566 WP_000212724.1 NZ_CP086118:c4215484-4215242 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT222566 NZ_CP117962:c1803101-1802805 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References