Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3501793..3502413 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LLY43_RS17245 Protein ID WP_001280991.1
Coordinates 3502195..3502413 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LLY43_RS17240 Protein ID WP_000344807.1
Coordinates 3501793..3502167 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS17230 (3496932) 3496932..3498125 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LLY43_RS17235 (3498148) 3498148..3501297 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LLY43_RS17240 (3501793) 3501793..3502167 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LLY43_RS17245 (3502195) 3502195..3502413 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LLY43_RS17250 (3502592) 3502592..3503143 + 552 WP_001278792.1 maltose O-acetyltransferase -
LLY43_RS17255 (3503260) 3503260..3503730 + 471 WP_000136181.1 YlaC family protein -
LLY43_RS17260 (3503786) 3503786..3503926 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LLY43_RS17265 (3503932) 3503932..3504192 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LLY43_RS17270 (3504417) 3504417..3505967 + 1551 WP_000213139.1 EAL domain-containing protein -
LLY43_RS17280 (3506198) 3506198..3506587 + 390 WP_000961285.1 MGMT family protein -
LLY43_RS17285 (3506620) 3506620..3507189 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222561 WP_001280991.1 NZ_CP086118:3502195-3502413 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222561 NZ_CP117962:1153726-1153944 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222561 WP_000344807.1 NZ_CP086118:3501793-3502167 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222561 NZ_CP117962:1153326-1153700 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References