Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 579596..580224 Replicon plasmid pSR-1
Accession NZ_CP086112
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JL101_RS31175 Protein ID WP_203101834.1
Coordinates 579820..580224 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JL101_RS31170 Protein ID WP_211111273.1
Coordinates 579596..579820 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS31145 (JL101_031225) 575639..575833 - 195 WP_203101826.1 helix-turn-helix domain-containing protein -
JL101_RS31150 (JL101_031230) 575985..576875 + 891 WP_203101828.1 universal stress protein -
JL101_RS31155 (JL101_031235) 576925..577749 + 825 WP_203101830.1 universal stress protein -
JL101_RS31160 (JL101_031240) 577814..578683 + 870 WP_203101832.1 formate/nitrite transporter family protein -
JL101_RS31165 (JL101_031245) 578709..579440 - 732 WP_203101891.1 DUF2270 domain-containing protein -
JL101_RS31170 (JL101_031250) 579596..579820 + 225 WP_211111273.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JL101_RS31175 (JL101_031255) 579820..580224 + 405 WP_203101834.1 type II toxin-antitoxin system VapC family toxin Toxin
JL101_RS31180 (JL101_031260) 580286..581134 - 849 WP_201082897.1 sugar phosphate isomerase/epimerase family protein -
JL101_RS31185 (JL101_031265) 581170..582195 - 1026 WP_203101835.1 ABC transporter permease -
JL101_RS31190 (JL101_031270) 582192..583217 - 1026 WP_203101836.1 ABC transporter permease -
JL101_RS31195 (JL101_031275) 583210..584691 - 1482 WP_203101837.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..612959 612959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14899.11 Da        Isoelectric Point: 6.4807

>T222543 WP_203101834.1 NZ_CP086112:579820-580224 [Skermanella rosea]
MLRFMLDTNVCIRVLRDRPPSARIRFNAESASLCISTVTLAELLHGAAKSGRPIEKRHEVERLVARLEVLPFDDEAAAHY
GEIRADLERSGTIIGPYDLMIAGHARSRGLVVVTGNLGEFSRVDGLRCEDWLEA

Download         Length: 405 bp

>T222543 NZ_CP117960:c2200411-2200238 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8444.54 Da        Isoelectric Point: 4.9987

>AT222543 WP_211111273.1 NZ_CP086112:579596-579820 [Skermanella rosea]
MAIRTSLFLSNRSQAVRLPKDVAFPPNVREVVILREGSRRVIVPADSLWDDFFNSPGVDFPDRDQPATQEREAF

Download         Length: 225 bp

>AT222543 NZ_CP117960:c2200735-2200439 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References