Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 521558..522098 Replicon plasmid pSR-1
Accession NZ_CP086112
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JL101_RS30935 Protein ID WP_203104403.1
Coordinates 521558..521851 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag JL101_RS30940 Protein ID WP_203104407.1
Coordinates 521832..522098 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS30920 (JL101_031000) 517038..519167 - 2130 WP_228435389.1 recombinase family protein -
JL101_RS30925 (JL101_031005) 519400..519741 + 342 Protein_464 IS701 family transposase -
JL101_RS30930 (JL101_031010) 519775..521199 - 1425 WP_203104400.1 ISNCY family transposase -
JL101_RS30935 (JL101_031015) 521558..521851 - 294 WP_203104403.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL101_RS30940 (JL101_031020) 521832..522098 - 267 WP_203104407.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JL101_RS30945 (JL101_031025) 522269..522940 - 672 WP_203104410.1 haloacid dehalogenase type II -
JL101_RS30950 (JL101_031030) 523393..523947 + 555 WP_203104413.1 cysteine hydrolase family protein -
JL101_RS30955 (JL101_031035) 524142..525194 + 1053 WP_203104416.1 sugar ABC transporter substrate-binding protein -
JL101_RS30960 (JL101_031040) 525295..526809 + 1515 WP_203104419.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..612959 612959
- flank IS/Tn - - 516049..517026 977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(1-82)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11622.29 Da        Isoelectric Point: 6.7501

>T222542 WP_203104403.1 NZ_CP086112:c521851-521558 [Skermanella rosea]
MNFKTTEKADEDIIGIYVYGMRRFGTEQAERYHAGLIECFSFLCEHPFAARERSEFDPPVRLYFHQAHVVVYLVRDDILL
IVRVLHGRQDWERHLRP

Download         Length: 294 bp

>T222542 NZ_CP117960:1990462-1990803 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGTTGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCCGCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9787.87 Da        Isoelectric Point: 4.8605

>AT222542 WP_203104407.1 NZ_CP086112:c522098-521832 [Skermanella rosea]
MATMNVSLPDPMKDWVEAQARSGRYSNASDYVRDLIRKDQERVGRLAELQGLIDEGIASGTSGRSMGEILHEARRRAEAP
GKNELQDD

Download         Length: 267 bp

>AT222542 NZ_CP117960:c1990467-1990391 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References