Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3717667..3718267 Replicon chromosome
Accession NZ_CP086111
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JL101_RS17360 Protein ID WP_228435502.1
Coordinates 3717667..3717837 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JL101_RS17365 Protein ID WP_203097232.1
Coordinates 3717875..3718267 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS17325 (JL101_017365) 3713014..3713904 + 891 WP_203097238.1 LysR substrate-binding domain-containing protein -
JL101_RS17330 (JL101_017370) 3714188..3714364 + 177 WP_203097237.1 hypothetical protein -
JL101_RS17335 (JL101_017375) 3714401..3714781 + 381 WP_203097236.1 hypothetical protein -
JL101_RS17340 (JL101_017380) 3714791..3714892 + 102 WP_228434918.1 DUF4412 domain-containing protein -
JL101_RS17345 (JL101_017385) 3715231..3715884 - 654 WP_203097235.1 hypothetical protein -
JL101_RS17350 (JL101_017390) 3716976..3717160 - 185 Protein_3417 IS5/IS1182 family transposase -
JL101_RS17355 (JL101_017395) 3717163..3717501 + 339 WP_203097234.1 LysR substrate-binding domain-containing protein -
JL101_RS17360 (JL101_017400) 3717667..3717837 + 171 WP_228435502.1 type II toxin-antitoxin system HicA family toxin Toxin
JL101_RS17365 (JL101_017405) 3717875..3718267 + 393 WP_203097232.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL101_RS17370 (JL101_017410) 3718428..3718772 - 345 WP_201079003.1 winged helix-turn-helix transcriptional regulator -
JL101_RS17375 (JL101_017415) 3718769..3719062 - 294 WP_201079001.1 DUF6516 family protein -
JL101_RS17380 (JL101_017420) 3719494..3720654 - 1161 WP_203097231.1 trypsin-like peptidase domain-containing protein -
JL101_RS17385 (JL101_017425) 3720703..3721899 - 1197 WP_203097230.1 M20 family metallopeptidase -
JL101_RS17390 (JL101_017430) 3721896..3722681 - 786 WP_203097229.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-53)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-124)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6406.44 Da        Isoelectric Point: 10.6654

>T222538 WP_228435502.1 NZ_CP086111:3717667-3717837 [Skermanella rosea]
IKRLMDDGWYEANQVGSHKKFKHPTKPGFVTVAHPAKDYPPKTLRSMETQAGIKLR

Download         Length: 171 bp

>T222538 NZ_CP117960:994608-994994 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13821.50 Da        Isoelectric Point: 4.3566

>AT222538 WP_203097232.1 NZ_CP086111:3717875-3718267 [Skermanella rosea]
MSVRYFPAIVEQGSDGFYVSFPDVPGCVSHGATLEELAANAEAALALHLAESAEDGRDLPVPSALGDTPVDPDEPEVCRL
LVRAELPGKSVRINISMDEGLLTAIDAEAKRRDTSRSGFLSAAARRELGR

Download         Length: 393 bp

>AT222538 NZ_CP117960:994984-995313 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References