Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1858648..1859254 Replicon chromosome
Accession NZ_CP086111
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JL101_RS08550 Protein ID WP_203099123.1
Coordinates 1858648..1858938 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JL101_RS08555 Protein ID WP_203099122.1
Coordinates 1858949..1859254 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS08530 (JL101_008545) 1853852..1854511 - 660 WP_203099127.1 ribonuclease HII -
JL101_RS08535 (JL101_008550) 1854575..1856179 - 1605 WP_203099126.1 GMC family oxidoreductase -
JL101_RS08540 (JL101_008555) 1856239..1857258 - 1020 WP_203099125.1 glycosyltransferase -
JL101_RS08545 (JL101_008560) 1857494..1858570 + 1077 WP_203099124.1 PA0069 family radical SAM protein -
JL101_RS08550 (JL101_008565) 1858648..1858938 + 291 WP_203099123.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL101_RS08555 (JL101_008570) 1858949..1859254 + 306 WP_203099122.1 putative addiction module antidote protein Antitoxin
JL101_RS08560 (JL101_008575) 1859337..1859579 + 243 WP_203099121.1 DUF1902 domain-containing protein -
JL101_RS08565 (JL101_008580) 1859668..1860618 - 951 WP_228435359.1 phosphotransferase -
JL101_RS08570 (JL101_008585) 1860626..1861174 - 549 WP_203099120.1 molybdenum cofactor biosynthesis protein B -
JL101_RS08575 (JL101_008590) 1861161..1862819 - 1659 WP_203099119.1 lytic transglycosylase domain-containing protein -
JL101_RS08580 (JL101_008595) 1863114..1863971 - 858 WP_203099118.1 uracil-DNA glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1856239..1863971 7732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10874.47 Da        Isoelectric Point: 7.9730

>T222533 WP_203099123.1 NZ_CP086111:1858648-1858938 [Skermanella rosea]
MIEIQQTDLFAAWIESVRDDRARLRVETRIRRLQLGNPGDVNPVGEGVSEMRIDYGPGYRVYFTCRGRTVIVLLAGGDKR
TQDLDIAAAIRLAREL

Download         Length: 291 bp

>T222533 NZ_CP117960:202184-202471 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10779.28 Da        Isoelectric Point: 4.6310

>AT222533 WP_203099122.1 NZ_CP086111:1858949-1859254 [Skermanella rosea]
MSKTETRPWDIVDSLTNEERIAAYLEAVLEDGDPELVAAALGDIARAKGMTDIARRTGLGRQSLYKALAPGGNPEFATVL
KVIRSLGLRLTVTVDPEGPGT

Download         Length: 306 bp

>AT222533 NZ_CP117960:201945-202184 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References