Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 840615..841194 Replicon chromosome
Accession NZ_CP086111
Organism Skermanella rosea strain KEMB 2255-458

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JL101_RS03930 Protein ID WP_203098420.1
Coordinates 840615..840875 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JL101_RS03935 Protein ID WP_203098419.1
Coordinates 840868..841194 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL101_RS03900 (JL101_003910) 835993..836877 + 885 WP_203098423.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
JL101_RS03905 (JL101_003915) 836991..837419 + 429 WP_203098422.1 hypothetical protein -
JL101_RS03910 (JL101_003920) 837469..838278 - 810 WP_203098421.1 MetQ/NlpA family ABC transporter substrate-binding protein -
JL101_RS03915 (JL101_003925) 838370..839038 - 669 WP_158043980.1 methionine ABC transporter permease -
JL101_RS03920 (JL101_003930) 839007..840068 - 1062 WP_202681718.1 methionine ABC transporter ATP-binding protein -
JL101_RS03930 (JL101_003940) 840615..840875 + 261 WP_203098420.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL101_RS03935 (JL101_003945) 840868..841194 + 327 WP_203098419.1 helix-turn-helix transcriptional regulator Antitoxin
JL101_RS03940 (JL101_003950) 841906..843168 - 1263 WP_203098418.1 DUF4384 domain-containing protein -
JL101_RS03945 (JL101_003955) 843438..844073 + 636 WP_228435272.1 TetR/AcrR family transcriptional regulator -
JL101_RS03950 (JL101_003960) 844188..845375 + 1188 WP_228435273.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-106)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9666.16 Da        Isoelectric Point: 10.2752

>T222531 WP_203098420.1 NZ_CP086111:840615-840875 [Skermanella rosea]
VQIQILPKAAKDLKALAPPDRARVVSKIEQYAADPASLVNNVKALQGSDLFRLRVGDYRILFTVNEDGTVSVLLVHRVRH
RREAYD

Download         Length: 261 bp

>T222531 NZ_CP117959:c5023093-5022815 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11739.35 Da        Isoelectric Point: 4.4410

>AT222531 WP_203098419.1 NZ_CP086111:840868-841194 [Skermanella rosea]
MTETLTISRAEYDALTERVEDLEDILAAMNARGGQPMPLEWAGRIINGESAIRVWREFRGLSLRALAAKSGVSAGYLSEI
EAGKKPGSVEAYKALAEALDTSVDWLVL

Download         Length: 327 bp

>AT222531 NZ_CP117959:c5023356-5023096 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References