Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4415472..4416154 Replicon chromosome
Accession NZ_CP086106
Organism Skermanella mucosa strain KEMB 2255-438

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JL100_RS20535 Protein ID WP_202684628.1
Coordinates 4415726..4416154 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JL100_RS20530 Protein ID WP_202684627.1
Coordinates 4415472..4415729 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL100_RS20500 (JL100_020555) 4411249..4412364 - 1116 WP_202684624.1 5-(carboxyamino)imidazole ribonucleotide synthase -
JL100_RS20505 (JL100_020560) 4412361..4412828 - 468 WP_202684685.1 5-(carboxyamino)imidazole ribonucleotide mutase -
JL100_RS20510 (JL100_020565) 4412972..4413172 - 201 WP_158046558.1 DUF465 domain-containing protein -
JL100_RS20515 (JL100_020570) 4413370..4414455 + 1086 WP_202684625.1 ATP-dependent 6-phosphofructokinase -
JL100_RS20520 (JL100_020575) 4414445..4414987 + 543 WP_228420815.1 TIGR02444 family protein -
JL100_RS20525 (JL100_020580) 4415106..4415396 + 291 WP_202684626.1 hypothetical protein -
JL100_RS20530 (JL100_020585) 4415472..4415729 + 258 WP_202684627.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JL100_RS20535 (JL100_020590) 4415726..4416154 + 429 WP_202684628.1 type II toxin-antitoxin system VapC family toxin Toxin
JL100_RS20540 (JL100_020595) 4416144..4416770 - 627 WP_202684629.1 UbiX family flavin prenyltransferase -
JL100_RS20545 (JL100_020600) 4416777..4417472 - 696 WP_202684630.1 DUF1013 domain-containing protein -
JL100_RS20550 (JL100_020605) 4417617..4418624 - 1008 WP_202684631.1 NAD(P)H-quinone oxidoreductase -
JL100_RS20555 (JL100_020610) 4418781..4418963 + 183 WP_202684632.1 DUF1192 domain-containing protein -
JL100_RS20560 (JL100_020615) 4419028..4419882 + 855 WP_202684633.1 sulfite exporter TauE/SafE family protein -
JL100_RS20565 (JL100_020620) 4419895..4420611 - 717 WP_202684634.1 DUF599 domain-containing protein -
JL100_RS20570 (JL100_020625) 4420608..4420838 - 231 WP_202684635.1 ribbon-helix-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15262.59 Da        Isoelectric Point: 6.4619

>T222527 WP_202684628.1 NZ_CP086106:4415726-4416154 [Skermanella mucosa]
MIVDTSAVIAILELEPEAADFAGLIAKADTPWISAVAVVEAGILAESRRGPAGADELDRFLVRAKFQIIPFDHVQARIAR
QAFRRYGKGRHPASLNFGDCIAYSLSKASGKPLLFKGNDFGKTDVITCLPTSPLPVQDEPIA

Download         Length: 429 bp

>T222527 NZ_CP117959:c3707379-3707272 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9582.78 Da        Isoelectric Point: 4.7370

>AT222527 WP_202684627.1 NZ_CP086106:4415472-4415729 [Skermanella mucosa]
MPLDIKDPEADRLASELARRRGVSVAEAVLAALREQIRREDEKSNSSVTAGELLEIAKRYSSLPILDDRPEEEILGYDQH
GLPRR

Download         Length: 258 bp

>AT222527 NZ_CP117959:3707427-3707493 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References