Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2486349..2486989 Replicon chromosome
Accession NZ_CP086106
Organism Skermanella mucosa strain KEMB 2255-438

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JL100_RS11255 Protein ID WP_202679767.1
Coordinates 2486349..2486765 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JL100_RS11260 Protein ID WP_202679766.1
Coordinates 2486765..2486989 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL100_RS11230 (JL100_011270) 2481550..2481732 + 183 WP_202679771.1 hypothetical protein -
JL100_RS11235 (JL100_011275) 2481808..2483244 - 1437 WP_202679770.1 metalloprotease TldD -
JL100_RS11240 (JL100_011280) 2483367..2484962 - 1596 WP_202679769.1 lysine--tRNA ligase -
JL100_RS11245 (JL100_011285) 2485126..2485830 + 705 WP_202679890.1 ABC transporter permease -
JL100_RS11250 (JL100_011290) 2485841..2486125 - 285 WP_202679768.1 hypothetical protein -
JL100_RS11255 (JL100_011295) 2486349..2486765 - 417 WP_202679767.1 type II toxin-antitoxin system VapC family toxin Toxin
JL100_RS11260 (JL100_011300) 2486765..2486989 - 225 WP_202679766.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JL100_RS11265 (JL100_011305) 2487170..2488543 - 1374 WP_202679765.1 ATP-binding protein -
JL100_RS11270 (JL100_011310) 2488545..2489279 - 735 WP_202679764.1 response regulator -
JL100_RS11275 (JL100_011315) 2489468..2490037 + 570 WP_202679763.1 Spy/CpxP family protein refolding chaperone -
JL100_RS11280 (JL100_011320) 2490145..2490717 + 573 WP_202679762.1 septation protein A -
JL100_RS11285 (JL100_011325) 2490714..2491646 + 933 WP_228421205.1 DUF3445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15482.61 Da        Isoelectric Point: 7.2475

>T222525 WP_202679767.1 NZ_CP086106:c2486765-2486349 [Skermanella mucosa]
MRRFMLDTNVCIRVLRDRPASARTRFNDEADGLSISAVTLGELLHGAAKSDRPADMRREVERLAARLEVLPFDDEAAAHY
GDIRADLKRRGMVIGSYDLMIAGHARSRGLVVVTGNLREFRRVDGLRCEDWLDESPGS

Download         Length: 417 bp

>T222525 NZ_CP117959:c3204671-3204357 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8373.46 Da        Isoelectric Point: 5.7710

>AT222525 WP_202679766.1 NZ_CP086106:c2486989-2486765 [Skermanella mucosa]
MQARTTLFHSNRSQAVRLPKDVSFPPGVRDVLILREGPRRIIIPADSVWDDFFDSPGIGFPDRDQPAAQEREAL

Download         Length: 225 bp

>AT222525 NZ_CP117959:c3204360-3203944 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References