Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2138986..2140572 Replicon chromosome
Accession NZ_CP086104
Organism Ralstonia sp. RS650

Toxin (Protein)


Gene name hipA Uniprot ID A0A454TLL9
Locus tag LGV82_RS09860 Protein ID WP_058908490.1
Coordinates 2139235..2140572 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A223GLT8
Locus tag LGV82_RS09855 Protein ID WP_028853251.1
Coordinates 2138986..2139231 (+) Length 82 a.a.

Genomic Context

LGV82_RS09845LGV82_RS09850LGV82_RS09855LGV82_RS09860LGV82_RS09865LGV82_RS09870LGV82_RS09825LGV82_RS09830LGV82_RS09835LGV82_RS09840LGV82_RS09875LGV82_RS09880LGV82_RS09885
Location: 2137897..2138016 (120 bp)
Type: Others
Protein ID: Protein_1931
Location: 2138043..2138882 (840 bp)
Type: Others
Protein ID: WP_011001397.1
Location: 2138986..2139231 (246 bp)
Type: Antitoxin
Protein ID: WP_028853251.1
Location: 2139235..2140572 (1338 bp)
Type: Toxin
Protein ID: WP_058908490.1
Location: 2140569..2141771 (1203 bp)
Type: Others
Protein ID: WP_011001394.1
Location: 2141997..2142725 (729 bp)
Type: Others
Protein ID: WP_118872253.1
Location: 2135049..2135975 (927 bp)
Type: Others
Protein ID: WP_265069412.1
Location: 2135972..2136523 (552 bp)
Type: Others
Protein ID: WP_011001400.1
Location: 2136543..2137019 (477 bp)
Type: Others
Protein ID: WP_011001399.1
Location: 2137087..2137725 (639 bp)
Type: Others
Protein ID: WP_028853250.1
Location: 2142738..2143334 (597 bp)
Type: Others
Protein ID: WP_011001392.1
Location: 2143482..2144180 (699 bp)
Type: Others
Protein ID: WP_058908491.1
Location: 2144177..2144917 (741 bp)
Type: Others
Protein ID: WP_058908492.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LGV82_RS09825 (LGV82_09800)2135049..2135975-927WP_265069412.1muramoyltetrapeptide carboxypeptidase-
LGV82_RS09830 (LGV82_09805)2135972..2136523-552WP_011001400.1tRNA adenosine(34) deaminase TadA-
LGV82_RS09835 (LGV82_09810)2136543..2137019-477WP_011001399.16-carboxytetrahydropterin synthase QueD-
LGV82_RS09840 (LGV82_09815)2137087..2137725-639WP_028853250.17-carboxy-7-deazaguanine synthase-
LGV82_RS09845 (LGV82_09820)2137897..2138016+120Protein_19312-hydroxychromene-2-carboxylate isomerase-
LGV82_RS09850 (LGV82_09825)2138043..2138882+840WP_011001397.1oxaloacetate decarboxylase-
LGV82_RS09855 (LGV82_09830)2138986..2139231+246WP_028853251.1helix-turn-helix transcriptional regulatorAntitoxin
LGV82_RS09860 (LGV82_09835)2139235..2140572+1338WP_058908490.1type II toxin-antitoxin system HipA family toxinToxin
LGV82_RS09865 (LGV82_09840)2140569..2141771+1203WP_011001394.1MFS transporter-
LGV82_RS09870 (LGV82_09845)2141997..2142725+729WP_118872253.1DsbA family protein-
LGV82_RS09875 (LGV82_09850)2142738..2143334-597WP_011001392.1RNA 2',3'-cyclic phosphodiesterase-
LGV82_RS09880 (LGV82_09855)2143482..2144180-699WP_058908491.1protocatechuate 3,4-dioxygenase subunit alpha-
LGV82_RS09885 (LGV82_09860)2144177..2144917-741WP_058908492.1protocatechuate 3,4-dioxygenase subunit beta-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48680.74 Da        Isoelectric Point: 6.8816

>T222519 WP_058908490.1 NZ_CP086104:2139235-2140572 [Ralstonia sp. RS650]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVA
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T222519 NZ_CP117959:c2012624-2012370 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8482.80 Da        Isoelectric Point: 10.4693

>AT222519 WP_028853251.1 NZ_CP086104:2138986-2139231 [Ralstonia sp. RS650]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAAAAPAD
W

Download         Length: 246 bp

>AT222519 NZ_CP117959:c2012872-2012621 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A454TLL9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A223GLT8

References