Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3884375..3885032 Replicon chromosome
Accession NZ_CP086101
Organism Enterobacter ludwigii strain 994590

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag LL022_RS18425 Protein ID WP_014171514.1
Coordinates 3884375..3884785 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LL022_RS18430 Protein ID WP_003863437.1
Coordinates 3884766..3885032 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL022_RS18405 (LL022_18445) 3880373..3882106 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
LL022_RS18410 (LL022_18450) 3882112..3882825 - 714 WP_228176454.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LL022_RS18415 (LL022_18455) 3882849..3883745 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
LL022_RS18420 (LL022_18460) 3883847..3884368 + 522 WP_049023375.1 flavodoxin FldB -
LL022_RS18425 (LL022_18465) 3884375..3884785 - 411 WP_014171514.1 protein YgfX Toxin
LL022_RS18430 (LL022_18470) 3884766..3885032 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LL022_RS18435 (LL022_18475) 3885327..3886307 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
LL022_RS18440 (LL022_18480) 3886418..3887077 - 660 WP_014171517.1 hemolysin III family protein -
LL022_RS18445 (LL022_18485) 3887344..3888075 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
LL022_RS18450 (LL022_18490) 3888192..3889625 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T222514 WP_014171514.1 NZ_CP086101:c3884785-3884375 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T222514 NZ_CP117959:c1132598-1132491 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT222514 WP_003863437.1 NZ_CP086101:c3885032-3884766 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT222514 NZ_CP117959:1132645-1132711 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References