Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3783239..3783768 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag TBFG_RS17800 Protein ID WP_003417760.1
Coordinates 3783511..3783768 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag TBFG_RS17795 Protein ID WP_003417757.1
Coordinates 3783239..3783514 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS22565 3780037..3781474 - 1438 Protein_3475 FAD-binding oxidoreductase -
TBFG_RS17780 3781577..3781966 + 390 WP_003417745.1 DUF732 domain-containing protein -
TBFG_RS17785 3781980..3782273 - 294 WP_003417749.1 DUF3017 domain-containing protein -
TBFG_RS17790 3782270..3783115 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
TBFG_RS17795 3783239..3783514 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
TBFG_RS17800 3783511..3783768 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
TBFG_RS17805 3783810..3785000 + 1191 WP_012054356.1 NADH:flavin oxidoreductase -
TBFG_RS17810 3785117..3785485 + 369 WP_003417765.1 FHA domain-containing protein -
TBFG_RS17815 3785482..3786033 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
TBFG_RS17820 3786040..3786621 - 582 WP_003417769.1 ATP/GTP-binding protein -
TBFG_RS17825 3786602..3786970 - 369 WP_003417772.1 DUF742 domain-containing protein -
TBFG_RS17830 3786948..3787340 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T22251 WP_003417760.1 NC_009565:3783511-3783768 [Mycobacterium tuberculosis F11]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T22251 NC_009565:3783511-3783768 [Mycobacterium tuberculosis F11]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT22251 WP_003417757.1 NC_009565:3783239-3783514 [Mycobacterium tuberculosis F11]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT22251 NC_009565:3783239-3783514 [Mycobacterium tuberculosis F11]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References