Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 477321..477837 Replicon chromosome
Accession NZ_CP086101
Organism Enterobacter ludwigii strain 994590

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL022_RS02280 Protein ID WP_228176140.1
Coordinates 477553..477837 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL022_RS02275 Protein ID WP_228176144.1
Coordinates 477321..477563 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL022_RS02260 (LL022_02265) 473318..474058 + 741 WP_228176148.1 KDGP aldolase family protein -
LL022_RS02265 (LL022_02270) 474177..475313 + 1137 WP_228176146.1 lactonase family protein -
LL022_RS02270 (LL022_02275) 475333..477243 + 1911 WP_050737582.1 PRD domain-containing protein -
LL022_RS02275 (LL022_02280) 477321..477563 + 243 WP_228176144.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LL022_RS02280 (LL022_02285) 477553..477837 + 285 WP_228176140.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL022_RS02285 (LL022_02290) 477841..478305 - 465 WP_063157014.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LL022_RS02290 (LL022_02295) 478443..480581 - 2139 WP_020885401.1 anaerobic ribonucleoside-triphosphate reductase -
LL022_RS02295 (LL022_02300) 480949..481521 - 573 WP_032681842.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10948.72 Da        Isoelectric Point: 10.1619

>T222504 WP_228176140.1 NZ_CP086101:477553-477837 [Enterobacter ludwigii]
MSYELVFDPRAFKEWTRPGDTVKNQFKKKLANVLVNPWVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVITIGK
REKSAVYHDVNKRL

Download         Length: 285 bp

>T222504 NZ_CP117958:8788-9204 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9110.56 Da        Isoelectric Point: 5.1053

>AT222504 WP_228176144.1 NZ_CP086101:477321-477563 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGHMPVKMVTVSDSEDELIQTVRERLANPQKGIKVRLDEL

Download         Length: 243 bp

>AT222504 NZ_CP117958:8561-8791 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References