Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3884354..3885011 Replicon chromosome
Accession NZ_CP086100
Organism Enterobacter ludwigii strain 196

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag LL024_RS18425 Protein ID WP_014171514.1
Coordinates 3884354..3884764 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LL024_RS18430 Protein ID WP_003863437.1
Coordinates 3884745..3885011 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL024_RS18405 (LL024_18445) 3880352..3882085 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
LL024_RS18410 (LL024_18450) 3882091..3882804 - 714 WP_228176454.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LL024_RS18415 (LL024_18455) 3882828..3883724 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
LL024_RS18420 (LL024_18460) 3883826..3884347 + 522 WP_049023375.1 flavodoxin FldB -
LL024_RS18425 (LL024_18465) 3884354..3884764 - 411 WP_014171514.1 protein YgfX Toxin
LL024_RS18430 (LL024_18470) 3884745..3885011 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LL024_RS18435 (LL024_18475) 3885306..3886286 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
LL024_RS18440 (LL024_18480) 3886397..3887056 - 660 WP_014171517.1 hemolysin III family protein -
LL024_RS18445 (LL024_18485) 3887323..3888054 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
LL024_RS18450 (LL024_18490) 3888171..3889604 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T222503 WP_014171514.1 NZ_CP086100:c3884764-3884354 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T222503 NZ_CP117958:c4376-4071 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT222503 WP_003863437.1 NZ_CP086100:c3885011-3884745 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT222503 NZ_CP117958:c4596-4378 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References