Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3719299..3719973 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag TBFG_RS17595 Protein ID WP_003417282.1
Coordinates 3719299..3719727 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag TBFG_RS17600 Protein ID WP_003417286.1
Coordinates 3719731..3719973 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS17570 3715121..3715522 - 402 WP_003417264.1 cytidine deaminase -
TBFG_RS17575 3715663..3716097 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
TBFG_RS17580 3716094..3716528 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
TBFG_RS17585 3716657..3718429 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
TBFG_RS17590 3718429..3719220 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
TBFG_RS17595 3719299..3719727 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
TBFG_RS17600 3719731..3719973 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
TBFG_RS17605 3720095..3720709 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
TBFG_RS17610 3720706..3721371 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
TBFG_RS17615 3721372..3721905 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
TBFG_RS17620 3721902..3722276 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T22250 WP_003417282.1 NC_009565:c3719727-3719299 [Mycobacterium tuberculosis F11]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T22250 NC_009565:c3719727-3719299 [Mycobacterium tuberculosis F11]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT22250 WP_003417286.1 NC_009565:c3719973-3719731 [Mycobacterium tuberculosis F11]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT22250 NC_009565:c3719973-3719731 [Mycobacterium tuberculosis F11]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References