Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3937998..3938618 Replicon chromosome
Accession NZ_CP086099
Organism Enterobacter ludwigii strain 197

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag LL023_RS18765 Protein ID WP_014168902.1
Coordinates 3938400..3938618 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag LL023_RS18760 Protein ID WP_020885187.1
Coordinates 3937998..3938372 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL023_RS18750 (LL023_18795) 3933124..3934317 + 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LL023_RS18755 (LL023_18800) 3934340..3937486 + 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
LL023_RS18760 (LL023_18805) 3937998..3938372 + 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
LL023_RS18765 (LL023_18810) 3938400..3938618 + 219 WP_014168902.1 HHA domain-containing protein Toxin
LL023_RS18770 (LL023_18815) 3938828..3939379 + 552 WP_020885188.1 maltose O-acetyltransferase -
LL023_RS18775 (LL023_18820) 3939497..3939964 + 468 WP_020885189.1 YlaC family protein -
LL023_RS18780 (LL023_18825) 3939936..3941396 - 1461 WP_228175955.1 PLP-dependent aminotransferase family protein -
LL023_RS18785 (LL023_18830) 3941497..3942207 + 711 WP_014168897.1 GNAT family protein -
LL023_RS18790 (LL023_18835) 3942204..3942344 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LL023_RS18795 (LL023_18840) 3942347..3942607 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T222491 WP_014168902.1 NZ_CP086099:3938400-3938618 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T222491 NZ_CP117886:c1694595-1694311 [Serratia ureilytica]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT222491 WP_020885187.1 NZ_CP086099:3937998-3938372 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT222491 NZ_CP117886:c1694836-1694585 [Serratia ureilytica]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCTGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAATACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References