Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1189826..1190483 Replicon chromosome
Accession NZ_CP086099
Organism Enterobacter ludwigii strain 197

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag LL023_RS05750 Protein ID WP_014171514.1
Coordinates 1190073..1190483 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LL023_RS05745 Protein ID WP_003863437.1
Coordinates 1189826..1190092 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL023_RS05725 (LL023_05740) 1185233..1186666 - 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -
LL023_RS05730 (LL023_05745) 1186783..1187514 - 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
LL023_RS05735 (LL023_05750) 1187781..1188440 + 660 WP_014171517.1 hemolysin III family protein -
LL023_RS05740 (LL023_05755) 1188551..1189531 - 981 WP_020883730.1 tRNA-modifying protein YgfZ -
LL023_RS05745 (LL023_05760) 1189826..1190092 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LL023_RS05750 (LL023_05765) 1190073..1190483 + 411 WP_014171514.1 protein YgfX Toxin
LL023_RS05755 (LL023_05770) 1190490..1191011 - 522 WP_049023375.1 flavodoxin FldB -
LL023_RS05760 (LL023_05775) 1191113..1192009 + 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
LL023_RS05765 (LL023_05780) 1192033..1192746 + 714 WP_228176454.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LL023_RS05770 (LL023_05785) 1192752..1194485 + 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T222482 WP_014171514.1 NZ_CP086099:1190073-1190483 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T222482 NZ_CP117881:1949964-1950266 [Novosphingobium sp. KACC 22771]
GTGCCCCGCTTCCAGTTAACACGCGCCGCAGCCGATGATCTGACAGCCATCTTTCTTGAGGGCATCGAGCAGTTCGGTCT
GCCTCAGGCCGACGCCTATCACGAAGGGCTGAGCGCGATTTTCGCGTTTCTCGCAGACTATCCCCATGCCGCGCGCCTGC
GCGAGGAGATCTCACCGCCTGTTCGCGTGCATCCCTACAAGGCCCATCTCGTGATTTATGATGTGGGAGCTGAGGACGAG
GTCATCATTCTGCGTGTCCGGCATGGTCGGGAAGATTGGATATCCTCGAATTTCGATGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT222482 WP_003863437.1 NZ_CP086099:1189826-1190092 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT222482 NZ_CP117881:1949716-1949961 [Novosphingobium sp. KACC 22771]
ATGGCCACGATGAACATTTCTCTGCCCGACCCGATGAAGCAATGGGTGGAGGCGCAAGCTGACACCGGCCGGTATAGCAA
TGCCAGCGACTATGTGCGCGATCTTATCCGCCGTGATCAGGAACGCGCCGACAAGGTTTCCGTCATGCAGCGCCTGATCG
ATGAAGCCCGAGCGAGCGGCCTGAGTGATGAGACGATGGCGGACATCCGGGCGCGGGCGATAAGCCAGGCTGGTTTGCAA
GCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References