222481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic-DUF1778
Location 120585..121156 Replicon plasmid p_4-4_B
Accession NZ_CP086071
Organism Rhodococcus pyridinivorans strain 4-4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LLA01_RS24770 Protein ID WP_252174461.1
Coordinates 120779..121156 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LLA01_RS24765 Protein ID WP_252174460.1
Coordinates 120585..120782 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLA01_RS24745 (LLA01_24770) 115620..115963 + 344 Protein_111 transposase -
LLA01_RS24750 (LLA01_24775) 115985..117207 - 1223 Protein_112 IS110 family transposase -
LLA01_RS24755 (LLA01_24780) 117404..118798 + 1395 WP_252173125.1 IS1380 family transposase -
LLA01_RS24760 (LLA01_24785) 119662..120460 + 799 Protein_114 IS5/IS1182 family transposase -
LLA01_RS24765 (LLA01_24790) 120585..120782 + 198 WP_252174460.1 DUF1778 domain-containing protein Antitoxin
LLA01_RS24770 (LLA01_24795) 120779..121156 + 378 WP_252174461.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LLA01_RS24775 (LLA01_24800) 121384..121719 - 336 WP_252174462.1 hypothetical protein -
LLA01_RS24780 (LLA01_24805) 121884..122042 + 159 WP_252174463.1 hypothetical protein -
LLA01_RS24785 (LLA01_24810) 122115..122444 - 330 WP_252174464.1 carboxymuconolactone decarboxylase family protein -
LLA01_RS24790 (LLA01_24815) 122589..122933 - 345 WP_252174465.1 metal-sensitive transcriptional regulator -
LLA01_RS24795 (LLA01_24820) 122945..124987 - 2043 WP_252174581.1 heavy metal translocating P-type ATPase -
LLA01_RS24800 (LLA01_24825) 125170..125580 - 411 WP_252174466.1 YdhK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..185470 185470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(5-83)

Antitoxin

Vibrio phage ICP1, Orf50

(4-40)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 6.2144

>T222481 WP_252174461.1 NZ_CP086071:120779-121156 [Rhodococcus pyridinivorans]
VTFYLDRDDLLTIAARVNGGSPTVREMGLLDAAIARPQSTVFGVDAYPTLFEKAAALLHSIARNHALVDGNKRTAWAATW
LFLGYNGIRLRRGFDVDSAEALVNDTATGAHDVTSIAAALATFVA

Download         Length: 378 bp

>T222481 NZ_CP117881:707645-708958 [Novosphingobium sp. KACC 22771]
ATGGTGGACGTTCCCATCCACTACGAGGGCCGCCGGGTCGCCACGATCAGTGCGGATGGGCAGGCGACCCGTCTTGCCTA
TGACGATAGCTGGCTGGCGTCCGAGGATCGGTTTCCCGTCTCGCTGGCCATGCCGATCCGGCCAGAGCCCTATGACGAGT
CGCTGGTCCTCCCCTGGCTGATGAACCTCCTGCCCGAGGGCGAGCCGCTGCGTGCGATGACGCGCGCGCTCGGTGCCGCG
CCGGAAGACGCGCTCGGCCTCATCGCGCAGACCGGCAGCGATCTGGCCGGGGCGCTGAGCATGGCCCCGCAGCCGACGCG
CGGCGAGCCGGCCTATCGCGCGATCCCCGATGCCGATGCGCTGGAGCGGATCCTCAACGAGTTGCCAGCGCGGCCCTTTC
TGGTGGGCGAGGACGGCGTTTCGATGAGCCTTGCCGGGGCTCAGGAGAAGCTGCCCGTTGCCGTTATCGACGGGCAGATC
GCCGTGCCGACCAATGGTGCGCCGTCGACCCACATCCTCAAGCCCGACAATCCGCGCCTGTCCGGTAGCGTGCAGAACGA
GGCCTTGTGCATGGTGCTGGCCCGCCGCATTGGCCTGAACGTCGCGCCTGTGACAACCGGAGTTGCGGGCGGGCGCAGCT
ATCTGCTGGTCGAGCGTTATGACCGGGCGGGGATCGGCGGGGCCGTTCGCCGCATGCATCAGGAGGATTTCTGTCAGGCG
CTGGGCCGGGCGCCTGCCGCCAAGTATGAGTTCAACGGCACCGGAACGCGTGGCCCCTCGATTGCCGATATGTTTGCCCT
TGTGCGCCAGCATATGACGGCGCGTGACATCACCCGGCTGCTGGATGCGGTGATTTTCAACATCGCCATCGGCAATGTGG
ATTCGCATGCCAAGAACTACTCGATCCTGCTCGGCGCTGGTGCTCCGGAACTGGCGCCGCTCTATGATCTCATGACGGGC
CTCGCCTGGGTCAACATCACGCAGAACCATGCCCAGGCCATCGGAGGGCAGCGGCGTGGGCGTCATATTTATGGTCGCCA
TTGGCGCCGTATGGCTGAGGCGGCTGGCCTTGCCGCACGGGGGACGATCCAGCGGGTTGAACATGTTACCGCGCGATTGC
TGCGCGAATTGCCTGCTGCGGTGGAAGAGGTCGCGGCCATGCCTGCCGGTGCGGCGATGCTGGATATTTTCGCCAAGGAG
ATCGGAGAGCGGGCTAGCGAAGTTCGGGCGCACGCTGGGCAAGAAGGCGTGCCGGATGTGACGGATACAGCCAGCGACGA
TCAGACCAACGACGCAACGGCCTATCGGGGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7157.05 Da        Isoelectric Point: 5.0022

>AT222481 WP_252174460.1 NZ_CP086071:120585-120782 [Rhodococcus pyridinivorans]
MPGLNIQFTDDEQALIRDAAEREGVSLKAFVHNASLDAASSRKRLRSELLADIFDKSAELNARLA

Download         Length: 198 bp

>AT222481 NZ_CP117881:707433-707645 [Novosphingobium sp. KACC 22771]
ATGATCGACAACGCAACCCAATTTGGCGCAGCCATCGCCTCAGCCCGCAAGGCCCTTGGCCTCACGCAGCGGGAGCTGGC
GCTCGCGATCAACAGCGGTGAACGCTTCATCGTCGACCTGGAGGCGGGCAAGCCCACCGCACAACTCGGCAAGGCGCTGG
CGGCGGCCAAGGCGGTTGGCTTGCGGCTGACCGCCAACGGTCCGCAGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References