Detailed information of TA system TA222479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2654278..2655230
• Replicon: chromosome
• Accession: NZ_CP086069
• Organism: Rhodococcus pyridinivorans strain 4-4

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: LLA01_RS12360
• Protein ID: WP_252172754.1
• Coordinates: 2654278..2654847 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: V9X925
• Locus tag: LLA01_RS12365
• Protein ID: WP_024101066.1
• Coordinates: 2654844..2655230 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLA01_RS12360 (LLA01_12375)	2654278..2654847	-	570	WP_252172754.1	zeta toxin family protein	Toxin
LLA01_RS12365 (LLA01_12380)	2654844..2655230	-	387	WP_024101066.1	hypothetical protein	Antitoxin
LLA01_RS12370 (LLA01_12385)	2655437..2656507	+	1071	WP_138843340.1	methyltransferase domain-containing protein	-
LLA01_RS12375 (LLA01_12390)	2656577..2656942	+	366	WP_064255686.1	HNH endonuclease	-
LLA01_RS12380 (LLA01_12395)	2656987..2657505	-	519	WP_252172755.1	hypothetical protein	-
LLA01_RS12385 (LLA01_12400)	2658640..2659572	-	933	WP_252172756.1	TAXI family TRAP transporter solute-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-102)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20524.65 Da
• Isoelectric Point: 10.6895

>T222479 WP_252172754.1 NZ_CP086069:c2654847-2654278 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEAGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Nucleotide

• Length: 570 bp

>T222479 NZ_CP117876:c4063925-4063575 [Paenibacillus sp. KACC 21273]
TTGATCGTAAAACGTGGCGATGTATTTTTTGCAGATTTATCGCCCGTCGTCGGCTCCGAACAGGGCGGCGTGAGGCCGGT
TCTGGTTATCCAGAATGATATCGGCAACCGTTTCAGTCCAACGGTTATTGTGGCGGCAATTACGGCACAGATTCAAAAAG
CCAAATTGCCAACACATGTGGAGATTGACGCGAAATCTCATGGGTTTGATAGAGATTCCGTCATTTTGCTGGAACAGATT
CGAACTATTGATAAACAGCGTCTGACTGACAAAATCACACATCTGGATGAAGAAACAATGCGTCGTGTACATGATGCGCT
CCAGATCAGTTTGGGCTTAGTGGAATTTTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13980.46 Da
• Isoelectric Point: 4.8349

>AT222479 WP_024101066.1 NZ_CP086069:c2655230-2654844 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLAGGLARTDYAEVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT222479 NZ_CP117876:c4064210-4063929 [Paenibacillus sp. KACC 21273]
TTGGACAACATGCAAAATGCGCAGAGCATTATGATCCGTTTGCCGGATCAACTTCTGCAAGAAGTGGATGGTATCGCAGC
TTTAGAAGATTCCGATCGCAGTGAACTAATCAGAAAAGCCACAAAAATTTATCTCACTGAACGCAAAAAGCGGTATATCC
GTGAAGCGATGCAGCGTGGATATATGGAAATGGCCAAAATTAATCTGAGAATTGCTTGCGAAGCTTTTCATGCGGAGGAA
GAGGCGGACATCACTCTGGACCGTTTAGTTAGCGGGGTGTAG

Structures

Antitoxin

• AlphaFold DB: V9X925