Detailed information of TA system TA222478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 656204..656763
• Replicon: chromosome
• Accession: NZ_CP086069
• Organism: Rhodococcus pyridinivorans strain 4-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LLA01_RS03130
• Protein ID: WP_175427899.1
• Coordinates: 656485..656763 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LLA01_RS03125
• Protein ID: WP_024102980.1
• Coordinates: 656204..656488 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLA01_RS03100 (LLA01_03100)	651407..652033	+	627	WP_231911981.1	TetR/AcrR family transcriptional regulator	-
LLA01_RS03105 (LLA01_03105)	652030..652458	+	429	WP_019290063.1	HIT family protein	-
LLA01_RS03110 (LLA01_03110)	652463..654064	+	1602	WP_252173680.1	L-lactate permease	-
LLA01_RS03115 (LLA01_03115)	654141..655169	+	1029	WP_024102977.1	Dyp-type peroxidase	-
LLA01_RS03120 (LLA01_03120)	655166..655984	+	819	WP_006551857.1	family 1 encapsulin nanocompartment shell protein	-
LLA01_RS03125 (LLA01_03125)	656204..656488	+	285	WP_024102980.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LLA01_RS03130 (LLA01_03130)	656485..656763	+	279	WP_175427899.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LLA01_RS03135 (LLA01_03135)	656820..657299	-	480	WP_039585875.1	MarR family transcriptional regulator	-
LLA01_RS03140 (LLA01_03140)	657358..658110	-	753	WP_064060432.1	cutinase family protein	-
LLA01_RS03145 (LLA01_03145)	658260..658922	-	663	WP_024102984.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
LLA01_RS03150 (LLA01_03150)	659043..659873	+	831	WP_006551851.1	SDR family oxidoreductase	-
LLA01_RS03155 (LLA01_03155)	659918..660889	+	972	WP_006551850.1	phosphotriesterase	-
LLA01_RS03160 (LLA01_03160)	660926..661645	-	720	WP_252173681.1	2OG-Fe(II) oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (21-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10282.89 Da
• Isoelectric Point: 10.3570

>T222478 WP_175427899.1 NZ_CP086069:656485-656763 [Rhodococcus pyridinivorans]
MSTPDHPYRLVMARSAARAMARSLPEKVATAVYEFVTGPLLEKPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVE
VTAISHRADAYR

Nucleotide

• Length: 279 bp

>T222478 NZ_CP117874:4792497-4792784 [Pectobacterium carotovorum subsp. carotovorum]
ATGAGTTATCGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTCAAGCTCGATAAAACCATTCAGCAGCAATTTGC
CAAAAAACTAAAAGAATGCTGCGAAAATCCCCATATTCCTGCGGCAAAGTTACGAGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTACGAGGTTATTGACGACGTATTGATTATCGCCGTGGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGGTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10494.56 Da
• Isoelectric Point: 4.2336

>AT222478 WP_024102980.1 NZ_CP086069:656204-656488 [Rhodococcus pyridinivorans]
MTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVDVQ
ELTQLMRDARSSEE

Nucleotide

• Length: 285 bp

>AT222478 NZ_CP117874:4792249-4792500 [Pectobacterium carotovorum subsp. carotovorum]
ATGCCAAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAACTGAAAAAGAACCCAATGGCGACGGTCAATGCTGG
TGATGGCCTGCCTGTCGCTATCTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAGGAGCTGGTTAAGCTGATCGGTGAACGTAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA