Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4832154..4833662 Replicon chromosome
Accession NZ_CP086064
Organism Pseudomonas aeruginosa strain CCBH28525

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KK481_RS23380 Protein ID WP_012613851.1
Coordinates 4833075..4833662 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KK481_RS23375 Protein ID WP_019726549.1
Coordinates 4832154..4833008 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK481_RS23360 (KK481_023385) 4827574..4827783 + 210 WP_003115568.1 cold-shock protein -
KK481_RS23365 (KK481_023390) 4827843..4829717 - 1875 WP_019726548.1 MFS transporter -
KK481_RS23370 (KK481_023395) 4829892..4832057 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
KK481_RS23375 (KK481_023400) 4832154..4833008 - 855 WP_019726549.1 AraC family transcriptional regulator Antitoxin
KK481_RS23380 (KK481_023405) 4833075..4833662 - 588 WP_012613851.1 GNAT family protein Toxin
KK481_RS23385 (KK481_023410) 4833928..4837407 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T222474 WP_012613851.1 NZ_CP086064:c4833662-4833075 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

>T222474 NZ_CP117874:1740274-1740588 [Pectobacterium carotovorum subsp. carotovorum]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGTCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTCCAGGCACTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGCACTCAGGTAAAGGCGGCAATAGACTTCCTCATCGACGGGTTCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31880.18 Da        Isoelectric Point: 7.1639

>AT222474 WP_019726549.1 NZ_CP086064:c4833008-4832154 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFCHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT222474 NZ_CP117874:1740035-1740271 [Pectobacterium carotovorum subsp. carotovorum]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
CATCAATCTGAGTGCTACTCTGTCAACCGCCTTGGATGCGGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAAA
ACAGGGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAGCAGGGTTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References