Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 635730..636367 Replicon chromosome
Accession NZ_CP086064
Organism Pseudomonas aeruginosa strain CCBH28525

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KK481_RS02940 Protein ID WP_019725766.1
Coordinates 635730..635912 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KK481_RS02945 Protein ID WP_019725767.1
Coordinates 635945..636367 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK481_RS02920 (KK481_002920) 631610..631898 - 289 Protein_583 integrase core domain-containing protein -
KK481_RS02925 (KK481_002925) 631964..633340 + 1377 WP_076611796.1 IS30-like element ISPa37 family transposase -
KK481_RS02930 (KK481_002930) 633342..634224 - 883 Protein_585 IS3 family transposase -
KK481_RS02935 (KK481_002935) 634289..635153 - 865 Protein_586 site-specific integrase -
KK481_RS02940 (KK481_002940) 635730..635912 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
KK481_RS02945 (KK481_002945) 635945..636367 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KK481_RS02950 (KK481_002950) 636613..637584 - 972 WP_025982283.1 hypothetical protein -
KK481_RS02955 (KK481_002955) 637569..638261 - 693 WP_019725770.1 hypothetical protein -
KK481_RS02960 (KK481_002960) 638258..638800 - 543 WP_025982284.1 hypothetical protein -
KK481_RS02965 (KK481_002965) 638797..639720 - 924 WP_019725772.1 hypothetical protein -
KK481_RS02970 (KK481_002970) 639717..640193 - 477 WP_019725773.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 623361..724487 101126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T222468 WP_019725766.1 NZ_CP086064:635730-635912 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

>T222468 NZ_CP117874:459464-460762 [Pectobacterium carotovorum subsp. carotovorum]
ATGAATATTCTCACGGTGGCGCTTAATGGCATTGCCGTCGGGGCGCTAGCGAAGGGGGTTGGGAGCGATATGACGTTCAC
TTACTACCCTGATTGGCTGAGCCGTCCCGGTGCGCGCGCCATTTCTCTTTCATTGCCTCTACAGCGGGCCACCTATCGTG
GCGATGTGGTTTACAACTTCTTTGATAATTTATTACCTGACAACGACAGTATTCGCAGCAGGATTCAGGCTCGTTTTCGT
ATCGCGACGAAACAGCCCTTTGATTTACTGACTAGCATCGGTGGTGACTGCGTTGGTGCGATTCAGATCTATCCGGTCGA
TACACCTGTTGCACCTGTCACTGATGTACATGCAGAAGCGCTTGATAATGATGAGATTGAAGCGTTGCTGCAGGGTTATC
GGGAAGCGCCATTAGGGATGGCTACGGATCGTGAGGATTTTCGTATCTCTCTCGCCGGTGCGCAGGAAAAGACGGCGTTA
CTTTGGTATAAAAATCAGTGGCATCGTCCGCAGGGGAATACGCCGACCAGCCATATCTTCAAATTACCGATTGGTTATAT
TGCCAACAACAGCATTGACCTCAGCGATAGTGTTGAAAACGAGTGGTTATGCCTGAAAATCGCCGAAAAGTATGGCTTTA
CTGTCGCTCAGGCGGAAATTTCCCGATTTAACTCACAAAAAGTCTTGATCGTTGAACGCTTTGATCGTCGCTGGTCACGC
AGCGATAAGCCCTGGCTGATGCGTTTGCCACAGGAGGATTTTTGTCAGGCTCTGGGTATTGCGCCCGCGTTAAAATACGA
GTCTGACGGTGGCCCTGGCATTGAGAAATCAATGGCGCTCTTGCTCGGCTCACAACAGGCGATGCAGGATAGGGATACCT
TTTTTAAAAGCCAGATACTGTTTTGGATGCTAGCCGCGATTGATGGTCATGCGAAAAACTTCAGCGTATTTATCGAGCCA
GGTAGTGCATACCGTATGACGCCTTTATACGATGTGATATCCGCTTTTCCTTTCATGGGACCGGCAGGAATATCGGTCCA
GAAGGCGAAGATGGCGATGGCGGTTCTTGGGCGTAATCGTCATTTCCATTGGCATAAGATTTTGCCGCGGCACTATTTTT
CTAGCGCCAGACAAGTGGGCTATCCGCAGGAACGCGTTGCCGCAATGATGTCGGAGATGAAAGCGAATACGGAACGGGTC
ATTGCGGAGGTGGAGGCACTCCTTCCCGACGATTTTCCTGAACGTATCAGTCATCCTATTTTTGCGGGACTGCGATCGCA
GGCTGCTCGGCTTCCCTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT222468 WP_019725767.1 NZ_CP086064:635945-636367 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp

>AT222468 NZ_CP117874:459212-459460 [Pectobacterium carotovorum subsp. carotovorum]
ATGAAGATCACCTCTGCTGGCATGCTAGCCCATGCTATGCGCGATGAACGCAAAAAGCACAAACTGAATCAAAGCCAAGT
TGCCGAGAGTATGGGAATAAAGCAGTCCACGGTGTCTGATTTCGAGAATCACCCAGAAGGGACGCGGCTTGAAACATTGT
TCAAGCTGCTGGCGGCTCTGGATCTGGAACTTCATCTTTCCAAACGAGGGGAGCAACAAGCGGGTCAGGAATGGAGTGAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References