Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3650485..3651121 | Replicon | chromosome |
| Accession | NZ_CP086061 | ||
| Organism | Bacillus sp. BC1-43 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | LK685_RS19075 | Protein ID | WP_003156187.1 |
| Coordinates | 3650485..3650835 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | LK685_RS19080 | Protein ID | WP_003225183.1 |
| Coordinates | 3650840..3651121 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK685_RS19035 (3645529) | 3645529..3646128 | - | 600 | WP_003246608.1 | phosphoserine phosphatase RsbX | - |
| LK685_RS19040 (3646128) | 3646128..3646916 | - | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| LK685_RS19045 (3646882) | 3646882..3647364 | - | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
| LK685_RS19050 (3647361) | 3647361..3647690 | - | 330 | WP_144484224.1 | anti-sigma factor antagonist RsbV | - |
| LK685_RS19055 (3647752) | 3647752..3648759 | - | 1008 | WP_015252763.1 | phosphoserine phosphatase RsbU | - |
| LK685_RS19060 (3648771) | 3648771..3649172 | - | 402 | WP_003246640.1 | serine/threonine-protein kinase RsbT | - |
| LK685_RS19065 (3649176) | 3649176..3649541 | - | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| LK685_RS19070 (3649546) | 3649546..3650370 | - | 825 | WP_015252765.1 | RsbT co-antagonist protein RsbRA | - |
| LK685_RS19075 (3650485) | 3650485..3650835 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| LK685_RS19080 (3650840) | 3650840..3651121 | - | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| LK685_RS19085 (3651237) | 3651237..3652406 | - | 1170 | WP_106074084.1 | alanine racemase | - |
| LK685_RS19090 (3652521) | 3652521..3653537 | - | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| LK685_RS19095 (3653703) | 3653703..3654068 | - | 366 | WP_088325332.1 | holo-ACP synthase | - |
| LK685_RS19100 (3654163) | 3654163..3654762 | + | 600 | WP_131227133.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T222466 WP_003156187.1 NZ_CP086061:c3650835-3650485 [Bacillus sp. BC1-43]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T222466 NZ_CP117874:360721-361008 [Pectobacterium carotovorum subsp. carotovorum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCATTGAAGGAATGGAAAAAATTAGGGCACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCATGTTCCTTCAGCCCAACTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACGAAAGGTCGTTCTGCTTAA
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCATTGAAGGAATGGAAAAAATTAGGGCACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCATGTTCCTTCAGCCCAACTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACGAAAGGTCGTTCTGCTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT222466 WP_003225183.1 NZ_CP086061:c3651121-3650840 [Bacillus sp. BC1-43]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT222466 NZ_CP117874:360477-360731 [Pectobacterium carotovorum subsp. carotovorum]
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACCGTTGATGACCGGATGTCAGAACTAGCTGACGCGGAAGAGATTTCG
CCCGATGACCTATAA
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACCGTTGATGACCGGATGTCAGAACTAGCTGACGCGGAAGAGATTTCG
CCCGATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|