Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 2853744..2854660 | Replicon | chromosome |
| Accession | NZ_CP086061 | ||
| Organism | Bacillus sp. BC1-43 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | O34853 |
| Locus tag | LK685_RS14815 | Protein ID | WP_003244695.1 |
| Coordinates | 2853744..2854490 (+) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | LK685_RS14820 | Protein ID | WP_003232646.1 |
| Coordinates | 2854490..2854660 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK685_RS14790 (2848824) | 2848824..2848970 | - | 147 | WP_003244977.1 | hypothetical protein | - |
| LK685_RS14795 (2849071) | 2849071..2850021 | - | 951 | WP_229762410.1 | ring-cleaving dioxygenase | - |
| LK685_RS14800 (2850411) | 2850411..2851727 | + | 1317 | WP_229762411.1 | serine/threonine exchanger | - |
| LK685_RS14805 (2852003) | 2852003..2852620 | + | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| LK685_RS14810 (2852633) | 2852633..2853634 | + | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
| LK685_RS14815 (2853744) | 2853744..2854490 | + | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| LK685_RS14820 (2854490) | 2854490..2854660 | + | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| LK685_RS14825 (2854746) | 2854746..2854883 | + | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| LK685_RS14830 (2854920) | 2854920..2855813 | - | 894 | WP_003245230.1 | N-acetylmuramoyl-L-alanine amidase | - |
| LK685_RS14835 (2855826) | 2855826..2856089 | - | 264 | WP_167559902.1 | phage holin | - |
| LK685_RS14840 (2856102) | 2856102..2856380 | - | 279 | WP_069149453.1 | hemolysin XhlA family protein | - |
| LK685_RS14845 (2856489) | 2856489..2856662 | - | 174 | WP_041344793.1 | XkdX family protein | - |
| LK685_RS14850 (2856641) | 2856641..2857051 | - | 411 | WP_229762412.1 | hypothetical protein | - |
| LK685_RS14855 (2857061) | 2857061..2859031 | - | 1971 | WP_041344789.1 | pyocin knob domain-containing protein | - |
| LK685_RS14860 (2859034) | 2859034..2859306 | - | 273 | WP_003232665.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T222465 WP_003244695.1 NZ_CP086061:2853744-2854490 [Bacillus sp. BC1-43]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T222465 NZ_CP117874:c197051-196872 [Pectobacterium carotovorum subsp. carotovorum]
ATGGATAGCAGAACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACCATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA
ATGGATAGCAGAACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACCATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT222465 WP_003232646.1 NZ_CP086061:2854490-2854660 [Bacillus sp. BC1-43]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT222465 NZ_CP117874:c196844-196434 [Pectobacterium carotovorum subsp. carotovorum]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACAAGACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTGGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAATGTCACGCTGCCTAAGTCGCTGATTGATCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACAAGACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTGGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAATGTCACGCTGCCTAAGTCGCTGATTGATCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|