22246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3148258..3148862 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag TBFG_RS14985 Protein ID WP_003414492.1
Coordinates 3148258..3148650 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag TBFG_RS14990 Protein ID WP_003414495.1
Coordinates 3148647..3148862 (-) Length 72 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS14955 3143408..3144196 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
TBFG_RS14960 3144530..3145075 - 546 WP_003913758.1 DUF1802 family protein -
TBFG_RS14965 3145347..3146231 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
TBFG_RS14970 3146234..3147121 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
TBFG_RS14975 3147426..3147971 - 546 WP_003899500.1 DUF1802 family protein -
TBFG_RS14980 3147968..3148237 - 270 WP_003414489.1 DUF2277 family protein -
TBFG_RS14985 3148258..3148650 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
TBFG_RS14990 3148647..3148862 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
TBFG_RS14995 3148909..3149658 + 750 WP_003414497.1 enoyl-CoA hydratase -
TBFG_RS15000 3149737..3150819 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
TBFG_RS15005 3150812..3152122 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
TBFG_RS15010 3152125..3152952 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
TBFG_RS15015 3152949..3153860 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T22246 WP_003414492.1 NC_009565:c3148650-3148258 [Mycobacterium tuberculosis F11]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T22246 NC_009565:c3148650-3148258 [Mycobacterium tuberculosis F11]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT22246 WP_003414495.1 NC_009565:c3148862-3148647 [Mycobacterium tuberculosis F11]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT22246 NC_009565:c3148862-3148647 [Mycobacterium tuberculosis F11]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References