Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3279812..3281032 Replicon chromosome
Accession NZ_CP086016
Organism Pseudomonas aeruginosa isolate KB-PA_3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LKM46_RS15905 Protein ID WP_042170883.1
Coordinates 3279812..3280390 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LKM46_RS15910 Protein ID WP_042170884.1
Coordinates 3280478..3281032 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKM46_RS15890 (LKM46_15890) 3275090..3276367 + 1278 WP_003160086.1 TolC family protein -
LKM46_RS15895 (LKM46_15895) 3276357..3278526 + 2170 Protein_3147 type I secretion system permease/ATPase -
LKM46_RS15900 (LKM46_15900) 3278516..3279703 + 1188 WP_042170881.1 HlyD family efflux transporter periplasmic adaptor subunit -
LKM46_RS15905 (LKM46_15905) 3279812..3280390 - 579 WP_042170883.1 HD domain-containing protein Toxin
LKM46_RS15910 (LKM46_15910) 3280478..3281032 - 555 WP_042170884.1 helix-turn-helix transcriptional regulator Antitoxin
LKM46_RS15915 (LKM46_15915) 3281187..3283382 - 2196 WP_083556322.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LKM46_RS15920 (LKM46_15920) 3283387..3283848 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
LKM46_RS15925 (LKM46_15925) 3284179..3284502 + 324 WP_003102734.1 multidrug efflux SMR transporter -
LKM46_RS15930 (LKM46_15930) 3284515..3284913 + 399 WP_023436383.1 NADH-quinone oxidoreductase subunit A -
LKM46_RS15935 (LKM46_15935) 3284910..3285461 - 552 WP_033978785.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21825.64 Da        Isoelectric Point: 5.3655

>T222445 WP_042170883.1 NZ_CP086016:c3280390-3279812 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLGGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T222445 NZ_CP117853:2019263-2019595 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20472.60 Da        Isoelectric Point: 8.1590

>AT222445 WP_042170884.1 NZ_CP086016:c3281032-3280478 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLGEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPTRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANTSAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT222445 NZ_CP117853:2019005-2019262 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGATGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References