222439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 145174..146090 Replicon plasmid pKB-PA_F19-4
Accession NZ_CP086014
Organism Pseudomonas aeruginosa isolate KB-PA_F19

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag LLH04_RS31800 Protein ID WP_021018402.1
Coordinates 145566..146090 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag LLH04_RS31795 Protein ID WP_010792483.1
Coordinates 145174..145569 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLH04_RS31785 (LLH04_31805) 141197..141721 - 525 WP_010792479.1 hypothetical protein -
LLH04_RS31790 (LLH04_31810) 143030..144964 + 1935 WP_021018401.1 hypothetical protein -
LLH04_RS31795 (LLH04_31815) 145174..145569 + 396 WP_010792483.1 hypothetical protein Antitoxin
LLH04_RS31800 (LLH04_31820) 145566..146090 + 525 WP_021018402.1 RES family NAD+ phosphorylase Toxin
LLH04_RS31805 (LLH04_31825) 146136..147386 - 1251 WP_010792484.1 TerD family protein -
LLH04_RS31810 (LLH04_31830) 147583..148638 - 1056 WP_021018403.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
LLH04_RS31815 (LLH04_31835) 149016..149207 + 192 WP_010792486.1 hypothetical protein -
LLH04_RS31820 (LLH04_31840) 149629..150774 - 1146 WP_021018404.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaIMP-45 / blaOXA-1 / catB3 / qacE / sul1 / qnrVC6 / msr(E) / mph(E) / aph(3')-Ia / tet(C) / floR - 1..412187 412187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T222439 WP_021018402.1 NZ_CP086014:145566-146090 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T222439 NZ_CP117852:4506629-4506874 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT222439 WP_010792483.1 NZ_CP086014:145174-145569 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT222439 NZ_CP117852:c4506779-4506472 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A212BIN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References