Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4643146..4644404 Replicon chromosome
Accession NZ_CP086010
Organism Pseudomonas aeruginosa isolate KB-PA_F19

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag LLH04_RS21780 Protein ID WP_003112528.1
Coordinates 4643146..4643901 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag LLH04_RS21785 Protein ID WP_003086329.1
Coordinates 4644036..4644404 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLH04_RS21770 (LLH04_21780) 4638319..4640862 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
LLH04_RS21775 (LLH04_21785) 4641017..4642378 - 1362 WP_010895536.1 DNA recombination protein RmuC -
LLH04_RS21780 (LLH04_21790) 4643146..4643901 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
LLH04_RS21785 (LLH04_21795) 4644036..4644404 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
LLH04_RS21790 (LLH04_21800) 4644477..4645763 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
LLH04_RS21795 (LLH04_21805) 4645819..4647408 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
LLH04_RS21800 (LLH04_21810) 4647487..4647963 + 477 WP_003112531.1 hypothetical protein -
LLH04_RS21805 (LLH04_21815) 4647966..4648241 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T222436 WP_003112528.1 NZ_CP086010:c4643901-4643146 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T222436 NZ_CP117852:c2944650-2944339 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAGAGATTTCTCTTCTCCGGCAGAGCTACGAAAAGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT222436 WP_003086329.1 NZ_CP086010:c4644404-4644036 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT222436 NZ_CP117852:c2944342-2943923 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTAGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGTGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References