Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2471271..2472218 Replicon chromosome
Accession NZ_CP086010
Organism Pseudomonas aeruginosa isolate KB-PA_F19

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LLH04_RS11940 Protein ID WP_034010873.1
Coordinates 2472039..2472218 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LLH04_RS11935 Protein ID WP_228214486.1
Coordinates 2471271..2471993 (-) Length 241 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLH04_RS11905 (LLH04_11905) 2467113..2467331 + 219 WP_003451709.1 Cro/CI family transcriptional regulator -
LLH04_RS11910 (LLH04_11910) 2467700..2468272 + 573 WP_003103363.1 hypothetical protein -
LLH04_RS11915 (LLH04_11915) 2468854..2469033 + 180 Protein_2360 DnaT-like ssDNA-binding domain-containing protein -
LLH04_RS11920 (LLH04_11920) 2469068..2469829 + 762 WP_228214481.1 hypothetical protein -
LLH04_RS11925 (LLH04_11925) 2469822..2470271 + 450 WP_128723289.1 RusA family crossover junction endodeoxyribonuclease -
LLH04_RS11930 (LLH04_11930) 2470300..2471169 + 870 WP_128723290.1 hypothetical protein -
LLH04_RS11935 (LLH04_11935) 2471271..2471993 - 723 WP_228214486.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LLH04_RS11940 (LLH04_11940) 2472039..2472218 - 180 WP_034010873.1 type II toxin-antitoxin system HicA family toxin Toxin
LLH04_RS11945 (LLH04_11945) 2472303..2472611 + 309 WP_034010874.1 hypothetical protein -
LLH04_RS11950 (LLH04_11950) 2472614..2472910 + 297 WP_034010876.1 hypothetical protein -
LLH04_RS11955 (LLH04_11955) 2472923..2473519 + 597 WP_128723291.1 terminase small subunit -
LLH04_RS11960 (LLH04_11960) 2473506..2474801 + 1296 WP_128723292.1 terminase family protein -
LLH04_RS11965 (LLH04_11965) 2474804..2476159 + 1356 WP_034010879.1 DUF4055 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2434400..2513002 78602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6590.68 Da        Isoelectric Point: 11.2336

>T222434 WP_034010873.1 NZ_CP086010:c2472218-2472039 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKTTTFANHGAKEMPEPTRKAIIKQLGL

Download         Length: 180 bp

>T222434 NZ_CP117852:c1925674-1925147 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGCTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 241 a.a.        Molecular weight: 27041.54 Da        Isoelectric Point: 4.7445

>AT222434 WP_228214486.1 NZ_CP086010:c2471993-2471271 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSFGDDREHAIQEAMDAIETTLSLYVDARKPIPEATPPEEGEHVVHLPAVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHNTKMDAVEAALLALGTRLRQSVEVRFDWVKLRHERADDVILVE
VWCEMVSSGHDETGNEQGWVSLPSQLSTTWNQIKAMEAHQFATGRQFSISVDDDRPGESRFESLGRIHLPVTFYAARVSA

Download         Length: 723 bp

>AT222434 NZ_CP117852:c1925961-1925671 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCGGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References