Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4345186..4345846 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LKX03_RS21870 Protein ID WP_000244756.1
Coordinates 4345186..4345599 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LKX03_RS21875 Protein ID WP_000351186.1
Coordinates 4345580..4345846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS21850 (4341127) 4341127..4342860 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
LKX03_RS21855 (4342866) 4342866..4343579 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LKX03_RS21860 (4343603) 4343603..4344499 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LKX03_RS21865 (4344612) 4344612..4345133 + 522 WP_001055885.1 flavodoxin FldB -
LKX03_RS21870 (4345186) 4345186..4345599 - 414 WP_000244756.1 protein YgfX Toxin
LKX03_RS21875 (4345580) 4345580..4345846 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LKX03_RS21880 (4346096) 4346096..4347076 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LKX03_RS21885 (4347192) 4347192..4347851 - 660 WP_000250289.1 hemolysin III family protein -
LKX03_RS21890 (4348015) 4348015..4348326 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LKX03_RS21895 (4348485) 4348485..4349918 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T222428 WP_000244756.1 NZ_CP085987:c4345599-4345186 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T222428 NZ_CP117852:1035204-1035512 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT222428 WP_000351186.1 NZ_CP085987:c4345846-4345580 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222428 NZ_CP117852:1034962-1035201 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGCGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References