Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3500596..3501356 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LKX03_RS17700 Protein ID WP_000533909.1
Coordinates 3500871..3501356 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LKX03_RS17695 Protein ID WP_000965886.1
Coordinates 3500596..3500883 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS17670 (3495891) 3495891..3496193 + 303 WP_000605590.1 YsaB family lipoprotein -
LKX03_RS17675 (3496332) 3496332..3497243 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LKX03_RS17680 (3497253) 3497253..3499322 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
LKX03_RS17685 (3499504) 3499504..3499779 + 276 Protein_3366 IS3 family transposase -
LKX03_RS17690 (3499951) 3499951..3500418 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LKX03_RS17695 (3500596) 3500596..3500883 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LKX03_RS17700 (3500871) 3500871..3501356 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LKX03_RS17705 (3501728) 3501728..3502267 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
LKX03_RS17710 (3502441) 3502441..3502653 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LKX03_RS17715 (3502942) 3502942..3503232 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LKX03_RS17720 (3503671) 3503671..3504381 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LKX03_RS17725 (3504431) 3504431..3505405 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
LKX03_RS17730 (3505624) 3505624..3506286 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T222423 WP_000533909.1 NZ_CP085987:3500871-3501356 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T222423 NZ_CP117851:c4107726-4107623 [Salmonella enterica subsp. enterica serovar Mbandaka]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT222423 WP_000965886.1 NZ_CP085987:3500596-3500883 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT222423 NZ_CP117851:4107621-4107764 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAAGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References