Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2757695..2758476 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LKX03_RS14220 Protein ID WP_000626099.1
Coordinates 2757695..2758186 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LKX03_RS14225 Protein ID WP_001110452.1
Coordinates 2758183..2758476 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS14180 (2752881) 2752881..2753123 - 243 WP_197603740.1 hypothetical protein -
LKX03_RS14185 (2753120) 2753120..2753476 - 357 WP_033567083.1 hypothetical protein -
LKX03_RS14190 (2753473) 2753473..2754345 - 873 WP_033567082.1 ParA family protein -
LKX03_RS14195 (2754536) 2754536..2754613 - 78 Protein_2696 helix-turn-helix domain-containing protein -
LKX03_RS14200 (2754704) 2754704..2755036 - 333 WP_001165471.1 MerR family transcriptional regulator -
LKX03_RS14205 (2755108) 2755108..2755485 + 378 WP_000916345.1 EthD family reductase -
LKX03_RS14210 (2756518) 2756518..2756592 + 75 Protein_2699 porin family protein -
LKX03_RS14215 (2756695) 2756695..2757447 + 753 WP_000842434.1 non-specific acid phosphatase -
LKX03_RS14220 (2757695) 2757695..2758186 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LKX03_RS14225 (2758183) 2758183..2758476 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LKX03_RS14230 (2758793) 2758793..2759014 + 222 WP_001576552.1 hypothetical protein -
LKX03_RS14235 (2759279) 2759279..2760154 + 876 WP_000921674.1 AraC family transcriptional regulator -
LKX03_RS14240 (2760151) 2760151..2760438 + 288 WP_001269916.1 transcriptional regulator RtsB -
LKX03_RS14245 (2760461) 2760461..2760676 + 216 WP_001595136.1 hypothetical protein -
LKX03_RS14250 (2760684) 2760684..2760953 + 270 WP_010989096.1 hypothetical protein -
LKX03_RS14255 (2761247) 2761247..2762152 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T222420 WP_000626099.1 NZ_CP085987:c2758186-2757695 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T222420 NZ_CP117851:c2719684-2719466 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT222420 WP_001110452.1 NZ_CP085987:c2758476-2758183 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT222420 NZ_CP117851:c2720086-2719712 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References