Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2757695..2758476 | Replicon | chromosome |
| Accession | NZ_CP085987 | ||
| Organism | Salmonella enterica strain SZL 38 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | LKX03_RS14220 | Protein ID | WP_000626099.1 |
| Coordinates | 2757695..2758186 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LKX03_RS14225 | Protein ID | WP_001110452.1 |
| Coordinates | 2758183..2758476 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LKX03_RS14180 (2752881) | 2752881..2753123 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| LKX03_RS14185 (2753120) | 2753120..2753476 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| LKX03_RS14190 (2753473) | 2753473..2754345 | - | 873 | WP_033567082.1 | ParA family protein | - |
| LKX03_RS14195 (2754536) | 2754536..2754613 | - | 78 | Protein_2696 | helix-turn-helix domain-containing protein | - |
| LKX03_RS14200 (2754704) | 2754704..2755036 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| LKX03_RS14205 (2755108) | 2755108..2755485 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| LKX03_RS14210 (2756518) | 2756518..2756592 | + | 75 | Protein_2699 | porin family protein | - |
| LKX03_RS14215 (2756695) | 2756695..2757447 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| LKX03_RS14220 (2757695) | 2757695..2758186 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| LKX03_RS14225 (2758183) | 2758183..2758476 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LKX03_RS14230 (2758793) | 2758793..2759014 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| LKX03_RS14235 (2759279) | 2759279..2760154 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| LKX03_RS14240 (2760151) | 2760151..2760438 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| LKX03_RS14245 (2760461) | 2760461..2760676 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| LKX03_RS14250 (2760684) | 2760684..2760953 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| LKX03_RS14255 (2761247) | 2761247..2762152 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T222420 WP_000626099.1 NZ_CP085987:c2758186-2757695 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T222420 NZ_CP117851:c2719684-2719466 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT222420 WP_001110452.1 NZ_CP085987:c2758476-2758183 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT222420 NZ_CP117851:c2720086-2719712 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|