Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2547617..2548133 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LKX03_RS13115 Protein ID WP_000220578.1
Coordinates 2547617..2547901 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LKX03_RS13120 Protein ID WP_000212724.1
Coordinates 2547891..2548133 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS13100 (2542829) 2542829..2544481 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
LKX03_RS13105 (2544890) 2544890..2547028 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LKX03_RS13110 (2547149) 2547149..2547613 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LKX03_RS13115 (2547617) 2547617..2547901 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKX03_RS13120 (2547891) 2547891..2548133 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LKX03_RS13125 (2548211) 2548211..2550124 - 1914 WP_001212137.1 BglG family transcription antiterminator -
LKX03_RS13130 (2550141) 2550141..2550881 - 741 WP_000779263.1 KDGP aldolase family protein -
LKX03_RS13135 (2550878) 2550878..2551996 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LKX03_RS13140 (2551980) 2551980..2553113 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T222419 WP_000220578.1 NZ_CP085987:c2547901-2547617 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T222419 NZ_CP117851:c2538439-2538194 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT222419 WP_000212724.1 NZ_CP085987:c2548133-2547891 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT222419 NZ_CP117851:2538289-2538596 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References